Neonatal Lupus Syndrome Associated with Ribonucleoprotein Antibodies

Neonatal lupus erythematosus (NLE) is a rare acquired autoimmune disease caused by transplacental transfer of maternal immunoglobulin G antibodies to the fetus. NLE has well‐recognized cutaneous features and may also manifest in other organs. The majority of cases are associated with Ro/SSA and La/S...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric dermatology 2013-07, Vol.30 (4), p.416-423
Main Authors: Heelan, Kara, Watson, Rosemarie, Collins, Sinead M.
Format: Article
Language:English
Subjects:
Autoantibodies - blood
Autoantibodies - immunology
Female
Humans
Infant
Infant, Newborn
Lupus Erythematosus, Cutaneous - diagnosis
Lupus Erythematosus, Cutaneous - immunology
Lupus Erythematosus, Systemic - congenital
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - immunology
Ribonucleoproteins - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neonatal lupus erythematosus (NLE) is a rare acquired autoimmune disease caused by transplacental transfer of maternal immunoglobulin G antibodies to the fetus. NLE has well‐recognized cutaneous features and may also manifest in other organs. The majority of cases are associated with Ro/SSA and La/SSB antibodies. Neonatal lupus due to antiribonucleoprotein (RNP) antibodies has rarely been reported. On rare occasions RNP has been found in association with other antibodies. We report a case of NLE occurring solely due to RNP antibodies presenting as varicelliform lesions at birth. We recorded the features in our case and 14 additional cases identified in the literature. It is important to recognize that maternal transfer of RNP antibodies may produce the classic cutaneous features of neonatal lupus. The limited case reports of this condition suggest that manifestations are limited to the skin; specifically, there are no reports of cardiac involvement. The long‐term outcome remains unknown. RNP‐positive, Ro/La‐negative NLE seems to represent a different clinical subset of NLE. The recognition of RNP antibody NLE as a benign condition limited to the skin is helpful in planning antenatal care for subsequent pregnancies.
ISSN:0736-8046
1525-1470
DOI:10.1111/pde.12088