Diagnostic accuracy of diffusion tensor imaging for pediatric cervical spinal cord injury

Study design: Cross-sectional non-experimental study. Objectives: To examine diagnostic accuracy of diffusion tensor imaging (DTI) for pediatric spinal cord injury (SCI). Setting Pediatric Orthopedic Hospital. Methods: Thirty-five subjects, 10 SCI and 25 controls, mean age 13.38 years underwent two...

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Bibliographic Details
Published in:Spinal cord 2013-07, Vol.51 (7), p.532-537
Main Authors: Mulcahey, M J, Samdani, A F, Gaughan, J P, Barakat, N, Faro, S, Shah, P, Betz, R R, Mohamed, F B
Format: Article
Language:English
Subjects:
631/1647/245/2149
692/699/375/1824
692/700/139
692/700/1720
Adolescent
Anatomy
Biomedical and Life Sciences
Biomedicine
Cervical Vertebrae - injuries
Cervical Vertebrae - pathology
Child
Diffusion Tensor Imaging - methods
Female
Human Physiology
Humans
Male
Neurochemistry
Neuropsychology
Neurosciences
original-article
Paralysis - diagnosis
Paralysis - etiology
Prognosis
Reproducibility of Results
Sensitivity and Specificity
Spinal Cord - pathology
Spinal Cord Injuries - complications
Spinal Cord Injuries - pathology
Young Adult
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Summary:Study design: Cross-sectional non-experimental study. Objectives: To examine diagnostic accuracy of diffusion tensor imaging (DTI) for pediatric spinal cord injury (SCI). Setting Pediatric Orthopedic Hospital. Methods: Thirty-five subjects, 10 SCI and 25 controls, mean age 13.38 years underwent two scans with 3.0 T MR scanner. Fractional anisotropy (FA), axial diffusivity (AD) and radial diffusivity (RD) values were calculated. Subjects with SCI underwent examination of muscle strength, sensation and sacral sparing. Mean and s.d. values for FA, AD and RD were compared by group (controls, SCI with sacral sparing, SCI without sacral sparing) using analysis of variance for repeated measures. Comparisons were also made of DTI values at the injury site to values from cervical regions outside of the injury site. Specificity, sensitivity, receiver operating characteristics area under the curve (ROC AUC) and corresponding 95% confidence intervals were calculated. Resampling methods were used to validate the estimates from the final models. Results: FA values differed among SCI subjects with intact sacral sparing, absent sacral sparing and controls, P
ISSN:1362-4393
1476-5624
DOI:10.1038/sc.2013.36