Diagnostic value of soluble CD14 subtype (sCD14-ST) presepsin for the postmortem diagnosis of sepsis-related fatalities

The first aim of this study was to assess the diagnostic performance of presepsin (sCD14-ST) in postmortem serum from femoral blood compared to procalcitonin (PCT) to detect sepsis-related fatalities. The second aim was to compare sCD14-ST levels found in postmortem serum to the values in pericardia...

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Bibliographic Details
Published in:International journal of legal medicine 2013-07, Vol.127 (4), p.799-808
Main Authors: Palmiere, Cristian, Mussap, Michele, Bardy, Daniel, Cibecchini, Francesco, Mangin, Patrice
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Angiography
Autopsies
Bacterial infections
Biochemistry
Biomarkers
Biomarkers - analysis
Calcitonin - analysis
Calcitonin Gene-Related Peptide
Case-Control Studies
Clinical medicine
Fatalities
Female
Forensic Medicine
Forensic Pathology
Histology
Hospitals
Humans
Infant
Infections
Infectious diseases
Lipopolysaccharide Receptors - analysis
Luminescent Measurements
Male
Medical imaging
Medical Law
Medical records
Medicine
Medicine & Public Health
Middle Aged
Neuropathology
Original Article
Pericardium - chemistry
Postmortem Changes
Protein Precursors - analysis
Proteins
Sensitivity and Specificity
Sepsis
Sepsis - diagnosis
Toxicology
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Summary:The first aim of this study was to assess the diagnostic performance of presepsin (sCD14-ST) in postmortem serum from femoral blood compared to procalcitonin (PCT) to detect sepsis-related fatalities. The second aim was to compare sCD14-ST levels found in postmortem serum to the values in pericardial fluid to investigate the usefulness of the latter as an alternative biological fluid. Two study groups were formed, a sepsis-related fatalities group and a control group. Radiology (unenhanced CT scans and postmortem angiographies), autopsies, histology, neuropathology, and toxicology as well as other postmortem biochemistry investigations were performed in all cases. Microbiological investigations on right cardiac blood were carried out exclusively in septic cases. The results of this study indicated that postmortem serum PCT and sCD14-ST levels, individually considered, allowed septic cases to be identified. Even though increases in both PCT and sCD14-ST concentrations were observed in the control cases, coherent PCT and sCD14-ST results in cases with suspected sepsis allowed the diagnosis to be confirmed. Conversely, no relevant correlation was identified between postmortem serum and pericardial fluid sCD14-ST levels in either the septic or control groups.
ISSN:0937-9827
1437-1596
DOI:10.1007/s00414-012-0804-5