Automated quantitative coronary computed tomography correlates of myocardial ischaemia on gated myocardial perfusion SPECT

Purpose Automated software tools have permitted more comprehensive, robust and reproducible quantification of coronary stenosis, plaque burden and plaque location of coronary computed tomography angiography (CTA) data. The association between these quantitative CTA (QCT) parameters and the presence...

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Published in:European journal of nuclear medicine and molecular imaging 2013-08, Vol.40 (8), p.1171-1180
Main Authors: de Graaf, Michiel A., El-Naggar, Heba M., Boogers, Mark J., Veltman, Caroline E., Broersen, Alexander, Kitslaar, Pieter H., Dijkstra, Jouke, Kroft, Lucia J., Al Younis, Imad, Reiber, Johan H., Bax, Jeroen J., Delgado, Victoria, Scholte, Arthur J.
Format: Article
Language:English
Subjects:
Aged
Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography
Cardiology
Coronary Artery Disease - diagnostic imaging
Coronary vessels
Coronary Vessels - diagnostic imaging
Female
Heart attacks
Humans
Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Myocardial Perfusion Imaging
Nuclear Medicine
Oncology
Original Article
Orthopedics
Radiology
Tomography
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Summary:Purpose Automated software tools have permitted more comprehensive, robust and reproducible quantification of coronary stenosis, plaque burden and plaque location of coronary computed tomography angiography (CTA) data. The association between these quantitative CTA (QCT) parameters and the presence of myocardial ischaemia has not been explored. The aim of the present investigation was to evaluate the association between QCT parameters of coronary artery lesions and the presence of myocardial ischaemia on gated myocardial perfusion single-photon emission CT (SPECT). Methods Included in the study were 40 patients (mean age 58.2 ± 10.9 years, 27 men) with known or suspected coronary artery disease (CAD) who had undergone multidetector row CTA and gated myocardial perfusion SPECT within 6 months. From the CTA datasets, vessel-based and lesion-based visual analyses were performed. Consecutively, lesion-based QCT was performed to assess plaque length, plaque burden, percentage lumen area stenosis and remodelling index. Subsequently, the presence of myocardial ischaemia was assessed using the summed difference score (SDS ≥2) on gated myocardial perfusion SPECT. Results Myocardial ischaemia was seen in 25 patients (62.5 %) in 37 vascular territories. Quantitatively assessed significant stenosis and quantitatively assessed lesion length were independently associated with myocardial ischaemia (OR 7.72, 95 % CI 2.41–24.7, p  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-013-2437-4