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Automated quantitative coronary computed tomography correlates of myocardial ischaemia on gated myocardial perfusion SPECT

Purpose Automated software tools have permitted more comprehensive, robust and reproducible quantification of coronary stenosis, plaque burden and plaque location of coronary computed tomography angiography (CTA) data. The association between these quantitative CTA (QCT) parameters and the presence...

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Published in:European journal of nuclear medicine and molecular imaging 2013-08, Vol.40 (8), p.1171-1180
Main Authors: de Graaf, Michiel A., El-Naggar, Heba M., Boogers, Mark J., Veltman, Caroline E., Broersen, Alexander, Kitslaar, Pieter H., Dijkstra, Jouke, Kroft, Lucia J., Al Younis, Imad, Reiber, Johan H., Bax, Jeroen J., Delgado, Victoria, Scholte, Arthur J.
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cited_by cdi_FETCH-LOGICAL-c405t-eca1b64e10ab8fdb22e20f348d62a4603936511fac9f262e322ca531545b0a623
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container_issue 8
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container_title European journal of nuclear medicine and molecular imaging
container_volume 40
creator de Graaf, Michiel A.
El-Naggar, Heba M.
Boogers, Mark J.
Veltman, Caroline E.
Broersen, Alexander
Kitslaar, Pieter H.
Dijkstra, Jouke
Kroft, Lucia J.
Al Younis, Imad
Reiber, Johan H.
Bax, Jeroen J.
Delgado, Victoria
Scholte, Arthur J.
description Purpose Automated software tools have permitted more comprehensive, robust and reproducible quantification of coronary stenosis, plaque burden and plaque location of coronary computed tomography angiography (CTA) data. The association between these quantitative CTA (QCT) parameters and the presence of myocardial ischaemia has not been explored. The aim of the present investigation was to evaluate the association between QCT parameters of coronary artery lesions and the presence of myocardial ischaemia on gated myocardial perfusion single-photon emission CT (SPECT). Methods Included in the study were 40 patients (mean age 58.2 ± 10.9 years, 27 men) with known or suspected coronary artery disease (CAD) who had undergone multidetector row CTA and gated myocardial perfusion SPECT within 6 months. From the CTA datasets, vessel-based and lesion-based visual analyses were performed. Consecutively, lesion-based QCT was performed to assess plaque length, plaque burden, percentage lumen area stenosis and remodelling index. Subsequently, the presence of myocardial ischaemia was assessed using the summed difference score (SDS ≥2) on gated myocardial perfusion SPECT. Results Myocardial ischaemia was seen in 25 patients (62.5 %) in 37 vascular territories. Quantitatively assessed significant stenosis and quantitatively assessed lesion length were independently associated with myocardial ischaemia (OR 7.72, 95 % CI 2.41–24.7, p  
doi_str_mv 10.1007/s00259-013-2437-4
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The association between these quantitative CTA (QCT) parameters and the presence of myocardial ischaemia has not been explored. The aim of the present investigation was to evaluate the association between QCT parameters of coronary artery lesions and the presence of myocardial ischaemia on gated myocardial perfusion single-photon emission CT (SPECT). Methods Included in the study were 40 patients (mean age 58.2 ± 10.9 years, 27 men) with known or suspected coronary artery disease (CAD) who had undergone multidetector row CTA and gated myocardial perfusion SPECT within 6 months. From the CTA datasets, vessel-based and lesion-based visual analyses were performed. Consecutively, lesion-based QCT was performed to assess plaque length, plaque burden, percentage lumen area stenosis and remodelling index. Subsequently, the presence of myocardial ischaemia was assessed using the summed difference score (SDS ≥2) on gated myocardial perfusion SPECT. Results Myocardial ischaemia was seen in 25 patients (62.5 %) in 37 vascular territories. Quantitatively assessed significant stenosis and quantitatively assessed lesion length were independently associated with myocardial ischaemia (OR 7.72, 95 % CI 2.41–24.7, p  &lt; 0.001, and OR 1.07, 95 % CI 1.00–1.45, p  = 0.032, respectively) after correcting for clinical variables and visually assessed significant stenosis. The addition of quantitatively assessed significant stenosis ( χ 2  = 20.7) and lesion length ( χ 2  = 26.0) to the clinical variables and the visual assessment ( χ 2  = 5.9) had incremental value in the association with myocardial ischaemia. Conclusion Coronary lesion length and quantitatively assessed significant stenosis were independently associated with myocardial ischaemia. Both quantitative parameters have incremental value over baseline variables and visually assessed significant stenosis. Potentially, QCT can refine assessment of CAD, which may be of potential use for identification of patients with myocardial ischaemia.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-013-2437-4</identifier><identifier>PMID: 23715901</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography ; Cardiology ; Coronary Artery Disease - diagnostic imaging ; Coronary vessels ; Coronary Vessels - diagnostic imaging ; Female ; Heart attacks ; Humans ; Imaging ; Male ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Myocardial Perfusion Imaging ; Nuclear Medicine ; Oncology ; Original Article ; Orthopedics ; Radiology ; Tomography</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2013-08, Vol.40 (8), p.1171-1180</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-eca1b64e10ab8fdb22e20f348d62a4603936511fac9f262e322ca531545b0a623</citedby><cites>FETCH-LOGICAL-c405t-eca1b64e10ab8fdb22e20f348d62a4603936511fac9f262e322ca531545b0a623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23715901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Graaf, Michiel A.</creatorcontrib><creatorcontrib>El-Naggar, Heba M.</creatorcontrib><creatorcontrib>Boogers, Mark J.</creatorcontrib><creatorcontrib>Veltman, Caroline E.</creatorcontrib><creatorcontrib>Broersen, Alexander</creatorcontrib><creatorcontrib>Kitslaar, Pieter H.</creatorcontrib><creatorcontrib>Dijkstra, Jouke</creatorcontrib><creatorcontrib>Kroft, Lucia J.</creatorcontrib><creatorcontrib>Al Younis, Imad</creatorcontrib><creatorcontrib>Reiber, Johan H.</creatorcontrib><creatorcontrib>Bax, Jeroen J.</creatorcontrib><creatorcontrib>Delgado, Victoria</creatorcontrib><creatorcontrib>Scholte, Arthur J.</creatorcontrib><title>Automated quantitative coronary computed tomography correlates of myocardial ischaemia on gated myocardial perfusion SPECT</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose Automated software tools have permitted more comprehensive, robust and reproducible quantification of coronary stenosis, plaque burden and plaque location of coronary computed tomography angiography (CTA) data. The association between these quantitative CTA (QCT) parameters and the presence of myocardial ischaemia has not been explored. The aim of the present investigation was to evaluate the association between QCT parameters of coronary artery lesions and the presence of myocardial ischaemia on gated myocardial perfusion single-photon emission CT (SPECT). Methods Included in the study were 40 patients (mean age 58.2 ± 10.9 years, 27 men) with known or suspected coronary artery disease (CAD) who had undergone multidetector row CTA and gated myocardial perfusion SPECT within 6 months. From the CTA datasets, vessel-based and lesion-based visual analyses were performed. Consecutively, lesion-based QCT was performed to assess plaque length, plaque burden, percentage lumen area stenosis and remodelling index. Subsequently, the presence of myocardial ischaemia was assessed using the summed difference score (SDS ≥2) on gated myocardial perfusion SPECT. Results Myocardial ischaemia was seen in 25 patients (62.5 %) in 37 vascular territories. Quantitatively assessed significant stenosis and quantitatively assessed lesion length were independently associated with myocardial ischaemia (OR 7.72, 95 % CI 2.41–24.7, p  &lt; 0.001, and OR 1.07, 95 % CI 1.00–1.45, p  = 0.032, respectively) after correcting for clinical variables and visually assessed significant stenosis. The addition of quantitatively assessed significant stenosis ( χ 2  = 20.7) and lesion length ( χ 2  = 26.0) to the clinical variables and the visual assessment ( χ 2  = 5.9) had incremental value in the association with myocardial ischaemia. Conclusion Coronary lesion length and quantitatively assessed significant stenosis were independently associated with myocardial ischaemia. Both quantitative parameters have incremental value over baseline variables and visually assessed significant stenosis. Potentially, QCT can refine assessment of CAD, which may be of potential use for identification of patients with myocardial ischaemia.</description><subject>Aged</subject><subject>Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography</subject><subject>Cardiology</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary vessels</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Myocardial Perfusion Imaging</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Radiology</subject><subject>Tomography</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkV9L3UAQxRepqFU_QF9KoC--pJ3Zf8k-ykVtQWhBfV4myeYaSbJxNxH007vXqyKF0qcd9vzmzOwexr4gfEeA4kcE4MrkgCLnUhS53GEHqNHkBZTm03tdwD77HOMdAJa8NHtsn4sClQE8YE-ny-wHml2T3S80zt1Mc_fgstoHP1J4TMUwLRs5YX4daLrd3IXg-tQUM99mw6OvKTQd9VkX61tyQ0eZH7P1i-sHdXKhXWKXpKs_Z6vrI7bbUh_d8et5yG7Oz65XP_PL3xe_VqeXeS1BzbmrCSstHQJVZdtUnDsOrZBlozlJDcIIrRBbqk3LNXeC85qUQCVVBaS5OGQnW98p-PvFxdkOaU_X9zQ6v0SLErlSBsvi_2gaVnJEoxL67S_0zi9hTA9JVCGE0VDoROGWqoOPMbjWTqEb0r9aBLvJ0G4ztClDu8nQytTz9dV5qQbXvHe8hZYAvgViksa1Cx9G_9P1GWhOp84</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>de Graaf, Michiel A.</creator><creator>El-Naggar, Heba M.</creator><creator>Boogers, Mark J.</creator><creator>Veltman, Caroline E.</creator><creator>Broersen, Alexander</creator><creator>Kitslaar, Pieter H.</creator><creator>Dijkstra, Jouke</creator><creator>Kroft, Lucia J.</creator><creator>Al Younis, Imad</creator><creator>Reiber, Johan H.</creator><creator>Bax, Jeroen J.</creator><creator>Delgado, Victoria</creator><creator>Scholte, Arthur J.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20130801</creationdate><title>Automated quantitative coronary computed tomography correlates of myocardial ischaemia on gated myocardial perfusion SPECT</title><author>de Graaf, Michiel A. ; 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The association between these quantitative CTA (QCT) parameters and the presence of myocardial ischaemia has not been explored. The aim of the present investigation was to evaluate the association between QCT parameters of coronary artery lesions and the presence of myocardial ischaemia on gated myocardial perfusion single-photon emission CT (SPECT). Methods Included in the study were 40 patients (mean age 58.2 ± 10.9 years, 27 men) with known or suspected coronary artery disease (CAD) who had undergone multidetector row CTA and gated myocardial perfusion SPECT within 6 months. From the CTA datasets, vessel-based and lesion-based visual analyses were performed. Consecutively, lesion-based QCT was performed to assess plaque length, plaque burden, percentage lumen area stenosis and remodelling index. Subsequently, the presence of myocardial ischaemia was assessed using the summed difference score (SDS ≥2) on gated myocardial perfusion SPECT. Results Myocardial ischaemia was seen in 25 patients (62.5 %) in 37 vascular territories. Quantitatively assessed significant stenosis and quantitatively assessed lesion length were independently associated with myocardial ischaemia (OR 7.72, 95 % CI 2.41–24.7, p  &lt; 0.001, and OR 1.07, 95 % CI 1.00–1.45, p  = 0.032, respectively) after correcting for clinical variables and visually assessed significant stenosis. The addition of quantitatively assessed significant stenosis ( χ 2  = 20.7) and lesion length ( χ 2  = 26.0) to the clinical variables and the visual assessment ( χ 2  = 5.9) had incremental value in the association with myocardial ischaemia. Conclusion Coronary lesion length and quantitatively assessed significant stenosis were independently associated with myocardial ischaemia. Both quantitative parameters have incremental value over baseline variables and visually assessed significant stenosis. Potentially, QCT can refine assessment of CAD, which may be of potential use for identification of patients with myocardial ischaemia.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23715901</pmid><doi>10.1007/s00259-013-2437-4</doi><tpages>10</tpages></addata></record>
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subjects Aged
Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography
Cardiology
Coronary Artery Disease - diagnostic imaging
Coronary vessels
Coronary Vessels - diagnostic imaging
Female
Heart attacks
Humans
Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Myocardial Perfusion Imaging
Nuclear Medicine
Oncology
Original Article
Orthopedics
Radiology
Tomography
title Automated quantitative coronary computed tomography correlates of myocardial ischaemia on gated myocardial perfusion SPECT
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T15%3A25%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Automated%20quantitative%20coronary%20computed%20tomography%20correlates%20of%20myocardial%20ischaemia%20on%20gated%20myocardial%20perfusion%20SPECT&rft.jtitle=European%20journal%20of%20nuclear%20medicine%20and%20molecular%20imaging&rft.au=de%20Graaf,%20Michiel%20A.&rft.date=2013-08-01&rft.volume=40&rft.issue=8&rft.spage=1171&rft.epage=1180&rft.pages=1171-1180&rft.issn=1619-7070&rft.eissn=1619-7089&rft_id=info:doi/10.1007/s00259-013-2437-4&rft_dat=%3Cproquest_cross%3E3010458231%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c405t-eca1b64e10ab8fdb22e20f348d62a4603936511fac9f262e322ca531545b0a623%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1373396076&rft_id=info:pmid/23715901&rfr_iscdi=true