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Automated quantitative coronary computed tomography correlates of myocardial ischaemia on gated myocardial perfusion SPECT
Purpose Automated software tools have permitted more comprehensive, robust and reproducible quantification of coronary stenosis, plaque burden and plaque location of coronary computed tomography angiography (CTA) data. The association between these quantitative CTA (QCT) parameters and the presence...
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Published in: | European journal of nuclear medicine and molecular imaging 2013-08, Vol.40 (8), p.1171-1180 |
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container_title | European journal of nuclear medicine and molecular imaging |
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creator | de Graaf, Michiel A. El-Naggar, Heba M. Boogers, Mark J. Veltman, Caroline E. Broersen, Alexander Kitslaar, Pieter H. Dijkstra, Jouke Kroft, Lucia J. Al Younis, Imad Reiber, Johan H. Bax, Jeroen J. Delgado, Victoria Scholte, Arthur J. |
description | Purpose
Automated software tools have permitted more comprehensive, robust and reproducible quantification of coronary stenosis, plaque burden and plaque location of coronary computed tomography angiography (CTA) data. The association between these quantitative CTA (QCT) parameters and the presence of myocardial ischaemia has not been explored. The aim of the present investigation was to evaluate the association between QCT parameters of coronary artery lesions and the presence of myocardial ischaemia on gated myocardial perfusion single-photon emission CT (SPECT).
Methods
Included in the study were 40 patients (mean age 58.2 ± 10.9 years, 27 men) with known or suspected coronary artery disease (CAD) who had undergone multidetector row CTA and gated myocardial perfusion SPECT within 6 months. From the CTA datasets, vessel-based and lesion-based visual analyses were performed. Consecutively, lesion-based QCT was performed to assess plaque length, plaque burden, percentage lumen area stenosis and remodelling index. Subsequently, the presence of myocardial ischaemia was assessed using the summed difference score (SDS ≥2) on gated myocardial perfusion SPECT.
Results
Myocardial ischaemia was seen in 25 patients (62.5 %) in 37 vascular territories. Quantitatively assessed significant stenosis and quantitatively assessed lesion length were independently associated with myocardial ischaemia (OR 7.72, 95 % CI 2.41–24.7,
p
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doi_str_mv | 10.1007/s00259-013-2437-4 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1412559187</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3010458231</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-eca1b64e10ab8fdb22e20f348d62a4603936511fac9f262e322ca531545b0a623</originalsourceid><addsrcrecordid>eNqFkV9L3UAQxRepqFU_QF9KoC--pJ3Zf8k-ykVtQWhBfV4myeYaSbJxNxH007vXqyKF0qcd9vzmzOwexr4gfEeA4kcE4MrkgCLnUhS53GEHqNHkBZTm03tdwD77HOMdAJa8NHtsn4sClQE8YE-ny-wHml2T3S80zt1Mc_fgstoHP1J4TMUwLRs5YX4daLrd3IXg-tQUM99mw6OvKTQd9VkX61tyQ0eZH7P1i-sHdXKhXWKXpKs_Z6vrI7bbUh_d8et5yG7Oz65XP_PL3xe_VqeXeS1BzbmrCSstHQJVZdtUnDsOrZBlozlJDcIIrRBbqk3LNXeC85qUQCVVBaS5OGQnW98p-PvFxdkOaU_X9zQ6v0SLErlSBsvi_2gaVnJEoxL67S_0zi9hTA9JVCGE0VDoROGWqoOPMbjWTqEb0r9aBLvJ0G4ztClDu8nQytTz9dV5qQbXvHe8hZYAvgViksa1Cx9G_9P1GWhOp84</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1373396076</pqid></control><display><type>article</type><title>Automated quantitative coronary computed tomography correlates of myocardial ischaemia on gated myocardial perfusion SPECT</title><source>Springer Link</source><creator>de Graaf, Michiel A. ; El-Naggar, Heba M. ; Boogers, Mark J. ; Veltman, Caroline E. ; Broersen, Alexander ; Kitslaar, Pieter H. ; Dijkstra, Jouke ; Kroft, Lucia J. ; Al Younis, Imad ; Reiber, Johan H. ; Bax, Jeroen J. ; Delgado, Victoria ; Scholte, Arthur J.</creator><creatorcontrib>de Graaf, Michiel A. ; El-Naggar, Heba M. ; Boogers, Mark J. ; Veltman, Caroline E. ; Broersen, Alexander ; Kitslaar, Pieter H. ; Dijkstra, Jouke ; Kroft, Lucia J. ; Al Younis, Imad ; Reiber, Johan H. ; Bax, Jeroen J. ; Delgado, Victoria ; Scholte, Arthur J.</creatorcontrib><description>Purpose
Automated software tools have permitted more comprehensive, robust and reproducible quantification of coronary stenosis, plaque burden and plaque location of coronary computed tomography angiography (CTA) data. The association between these quantitative CTA (QCT) parameters and the presence of myocardial ischaemia has not been explored. The aim of the present investigation was to evaluate the association between QCT parameters of coronary artery lesions and the presence of myocardial ischaemia on gated myocardial perfusion single-photon emission CT (SPECT).
Methods
Included in the study were 40 patients (mean age 58.2 ± 10.9 years, 27 men) with known or suspected coronary artery disease (CAD) who had undergone multidetector row CTA and gated myocardial perfusion SPECT within 6 months. From the CTA datasets, vessel-based and lesion-based visual analyses were performed. Consecutively, lesion-based QCT was performed to assess plaque length, plaque burden, percentage lumen area stenosis and remodelling index. Subsequently, the presence of myocardial ischaemia was assessed using the summed difference score (SDS ≥2) on gated myocardial perfusion SPECT.
Results
Myocardial ischaemia was seen in 25 patients (62.5 %) in 37 vascular territories. Quantitatively assessed significant stenosis and quantitatively assessed lesion length were independently associated with myocardial ischaemia (OR 7.72, 95 % CI 2.41–24.7,
p
< 0.001, and OR 1.07, 95 % CI 1.00–1.45,
p
= 0.032, respectively) after correcting for clinical variables and visually assessed significant stenosis. The addition of quantitatively assessed significant stenosis (
χ
2
= 20.7) and lesion length (
χ
2
= 26.0) to the clinical variables and the visual assessment (
χ
2
= 5.9) had incremental value in the association with myocardial ischaemia.
Conclusion
Coronary lesion length and quantitatively assessed significant stenosis were independently associated with myocardial ischaemia. Both quantitative parameters have incremental value over baseline variables and visually assessed significant stenosis. Potentially, QCT can refine assessment of CAD, which may be of potential use for identification of patients with myocardial ischaemia.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-013-2437-4</identifier><identifier>PMID: 23715901</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography ; Cardiology ; Coronary Artery Disease - diagnostic imaging ; Coronary vessels ; Coronary Vessels - diagnostic imaging ; Female ; Heart attacks ; Humans ; Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Myocardial Perfusion Imaging ; Nuclear Medicine ; Oncology ; Original Article ; Orthopedics ; Radiology ; Tomography</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2013-08, Vol.40 (8), p.1171-1180</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-eca1b64e10ab8fdb22e20f348d62a4603936511fac9f262e322ca531545b0a623</citedby><cites>FETCH-LOGICAL-c405t-eca1b64e10ab8fdb22e20f348d62a4603936511fac9f262e322ca531545b0a623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23715901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Graaf, Michiel A.</creatorcontrib><creatorcontrib>El-Naggar, Heba M.</creatorcontrib><creatorcontrib>Boogers, Mark J.</creatorcontrib><creatorcontrib>Veltman, Caroline E.</creatorcontrib><creatorcontrib>Broersen, Alexander</creatorcontrib><creatorcontrib>Kitslaar, Pieter H.</creatorcontrib><creatorcontrib>Dijkstra, Jouke</creatorcontrib><creatorcontrib>Kroft, Lucia J.</creatorcontrib><creatorcontrib>Al Younis, Imad</creatorcontrib><creatorcontrib>Reiber, Johan H.</creatorcontrib><creatorcontrib>Bax, Jeroen J.</creatorcontrib><creatorcontrib>Delgado, Victoria</creatorcontrib><creatorcontrib>Scholte, Arthur J.</creatorcontrib><title>Automated quantitative coronary computed tomography correlates of myocardial ischaemia on gated myocardial perfusion SPECT</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
Automated software tools have permitted more comprehensive, robust and reproducible quantification of coronary stenosis, plaque burden and plaque location of coronary computed tomography angiography (CTA) data. The association between these quantitative CTA (QCT) parameters and the presence of myocardial ischaemia has not been explored. The aim of the present investigation was to evaluate the association between QCT parameters of coronary artery lesions and the presence of myocardial ischaemia on gated myocardial perfusion single-photon emission CT (SPECT).
Methods
Included in the study were 40 patients (mean age 58.2 ± 10.9 years, 27 men) with known or suspected coronary artery disease (CAD) who had undergone multidetector row CTA and gated myocardial perfusion SPECT within 6 months. From the CTA datasets, vessel-based and lesion-based visual analyses were performed. Consecutively, lesion-based QCT was performed to assess plaque length, plaque burden, percentage lumen area stenosis and remodelling index. Subsequently, the presence of myocardial ischaemia was assessed using the summed difference score (SDS ≥2) on gated myocardial perfusion SPECT.
Results
Myocardial ischaemia was seen in 25 patients (62.5 %) in 37 vascular territories. Quantitatively assessed significant stenosis and quantitatively assessed lesion length were independently associated with myocardial ischaemia (OR 7.72, 95 % CI 2.41–24.7,
p
< 0.001, and OR 1.07, 95 % CI 1.00–1.45,
p
= 0.032, respectively) after correcting for clinical variables and visually assessed significant stenosis. The addition of quantitatively assessed significant stenosis (
χ
2
= 20.7) and lesion length (
χ
2
= 26.0) to the clinical variables and the visual assessment (
χ
2
= 5.9) had incremental value in the association with myocardial ischaemia.
Conclusion
Coronary lesion length and quantitatively assessed significant stenosis were independently associated with myocardial ischaemia. Both quantitative parameters have incremental value over baseline variables and visually assessed significant stenosis. Potentially, QCT can refine assessment of CAD, which may be of potential use for identification of patients with myocardial ischaemia.</description><subject>Aged</subject><subject>Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography</subject><subject>Cardiology</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary vessels</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Myocardial Perfusion Imaging</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Radiology</subject><subject>Tomography</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkV9L3UAQxRepqFU_QF9KoC--pJ3Zf8k-ykVtQWhBfV4myeYaSbJxNxH007vXqyKF0qcd9vzmzOwexr4gfEeA4kcE4MrkgCLnUhS53GEHqNHkBZTm03tdwD77HOMdAJa8NHtsn4sClQE8YE-ny-wHml2T3S80zt1Mc_fgstoHP1J4TMUwLRs5YX4daLrd3IXg-tQUM99mw6OvKTQd9VkX61tyQ0eZH7P1i-sHdXKhXWKXpKs_Z6vrI7bbUh_d8et5yG7Oz65XP_PL3xe_VqeXeS1BzbmrCSstHQJVZdtUnDsOrZBlozlJDcIIrRBbqk3LNXeC85qUQCVVBaS5OGQnW98p-PvFxdkOaU_X9zQ6v0SLErlSBsvi_2gaVnJEoxL67S_0zi9hTA9JVCGE0VDoROGWqoOPMbjWTqEb0r9aBLvJ0G4ztClDu8nQytTz9dV5qQbXvHe8hZYAvgViksa1Cx9G_9P1GWhOp84</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>de Graaf, Michiel A.</creator><creator>El-Naggar, Heba M.</creator><creator>Boogers, Mark J.</creator><creator>Veltman, Caroline E.</creator><creator>Broersen, Alexander</creator><creator>Kitslaar, Pieter H.</creator><creator>Dijkstra, Jouke</creator><creator>Kroft, Lucia J.</creator><creator>Al Younis, Imad</creator><creator>Reiber, Johan H.</creator><creator>Bax, Jeroen J.</creator><creator>Delgado, Victoria</creator><creator>Scholte, Arthur J.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20130801</creationdate><title>Automated quantitative coronary computed tomography correlates of myocardial ischaemia on gated myocardial perfusion SPECT</title><author>de Graaf, Michiel A. ; El-Naggar, Heba M. ; Boogers, Mark J. ; Veltman, Caroline E. ; Broersen, Alexander ; Kitslaar, Pieter H. ; Dijkstra, Jouke ; Kroft, Lucia J. ; Al Younis, Imad ; Reiber, Johan H. ; Bax, Jeroen J. ; Delgado, Victoria ; Scholte, Arthur J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-eca1b64e10ab8fdb22e20f348d62a4603936511fac9f262e322ca531545b0a623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography</topic><topic>Cardiology</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary vessels</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Myocardial Perfusion Imaging</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Radiology</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Graaf, Michiel A.</creatorcontrib><creatorcontrib>El-Naggar, Heba M.</creatorcontrib><creatorcontrib>Boogers, Mark J.</creatorcontrib><creatorcontrib>Veltman, Caroline E.</creatorcontrib><creatorcontrib>Broersen, Alexander</creatorcontrib><creatorcontrib>Kitslaar, Pieter H.</creatorcontrib><creatorcontrib>Dijkstra, Jouke</creatorcontrib><creatorcontrib>Kroft, Lucia J.</creatorcontrib><creatorcontrib>Al Younis, Imad</creatorcontrib><creatorcontrib>Reiber, Johan H.</creatorcontrib><creatorcontrib>Bax, Jeroen J.</creatorcontrib><creatorcontrib>Delgado, Victoria</creatorcontrib><creatorcontrib>Scholte, Arthur J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Graaf, Michiel A.</au><au>El-Naggar, Heba M.</au><au>Boogers, Mark J.</au><au>Veltman, Caroline E.</au><au>Broersen, Alexander</au><au>Kitslaar, Pieter H.</au><au>Dijkstra, Jouke</au><au>Kroft, Lucia J.</au><au>Al Younis, Imad</au><au>Reiber, Johan H.</au><au>Bax, Jeroen J.</au><au>Delgado, Victoria</au><au>Scholte, Arthur J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Automated quantitative coronary computed tomography correlates of myocardial ischaemia on gated myocardial perfusion SPECT</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>40</volume><issue>8</issue><spage>1171</spage><epage>1180</epage><pages>1171-1180</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
Automated software tools have permitted more comprehensive, robust and reproducible quantification of coronary stenosis, plaque burden and plaque location of coronary computed tomography angiography (CTA) data. The association between these quantitative CTA (QCT) parameters and the presence of myocardial ischaemia has not been explored. The aim of the present investigation was to evaluate the association between QCT parameters of coronary artery lesions and the presence of myocardial ischaemia on gated myocardial perfusion single-photon emission CT (SPECT).
Methods
Included in the study were 40 patients (mean age 58.2 ± 10.9 years, 27 men) with known or suspected coronary artery disease (CAD) who had undergone multidetector row CTA and gated myocardial perfusion SPECT within 6 months. From the CTA datasets, vessel-based and lesion-based visual analyses were performed. Consecutively, lesion-based QCT was performed to assess plaque length, plaque burden, percentage lumen area stenosis and remodelling index. Subsequently, the presence of myocardial ischaemia was assessed using the summed difference score (SDS ≥2) on gated myocardial perfusion SPECT.
Results
Myocardial ischaemia was seen in 25 patients (62.5 %) in 37 vascular territories. Quantitatively assessed significant stenosis and quantitatively assessed lesion length were independently associated with myocardial ischaemia (OR 7.72, 95 % CI 2.41–24.7,
p
< 0.001, and OR 1.07, 95 % CI 1.00–1.45,
p
= 0.032, respectively) after correcting for clinical variables and visually assessed significant stenosis. The addition of quantitatively assessed significant stenosis (
χ
2
= 20.7) and lesion length (
χ
2
= 26.0) to the clinical variables and the visual assessment (
χ
2
= 5.9) had incremental value in the association with myocardial ischaemia.
Conclusion
Coronary lesion length and quantitatively assessed significant stenosis were independently associated with myocardial ischaemia. Both quantitative parameters have incremental value over baseline variables and visually assessed significant stenosis. Potentially, QCT can refine assessment of CAD, which may be of potential use for identification of patients with myocardial ischaemia.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23715901</pmid><doi>10.1007/s00259-013-2437-4</doi><tpages>10</tpages></addata></record> |
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source | Springer Link |
subjects | Aged Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography Cardiology Coronary Artery Disease - diagnostic imaging Coronary vessels Coronary Vessels - diagnostic imaging Female Heart attacks Humans Imaging Male Medicine Medicine & Public Health Middle Aged Myocardial Perfusion Imaging Nuclear Medicine Oncology Original Article Orthopedics Radiology Tomography |
title | Automated quantitative coronary computed tomography correlates of myocardial ischaemia on gated myocardial perfusion SPECT |
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