Circulating oxidised LDL lipids, when proportioned to HDL-c, emerged as a risk factor of all-cause mortality in a population-based survival study

• Published in: Age and ageing 2013-01, Vol.42 (1), p.110-113
• Main Authors: Linna, Meri, Ahotupa, Markku, Löppönen, Minna K, Irjala, Kerttu, Vasankari, Tommi
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Apolipoprotein A-I - blood; Chemical properties; Cholesterol; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Elderly people; Female; Finland - epidemiology; Health aspects; Health risk assessment; Humans; Lipid research; Lipids; Lipoproteins; Lipoproteins, LDL - blood; Longitudinal Studies; Low density lipoproteins; Male; Medical research; Methods; Middle Aged; Mortality; Older people; Physiological aspects; Predictive Value of Tests; Proportional Hazards Models; Risk Factors
• ISSN: 0002-0729; 1468-2834
• DOI: 10.1093/ageing/afs074

the data concerning the predictive role of oxidised LDL (ox-LDL) in all-cause mortality are scarce. We investigated whether circulating ox-LDL would stand out as a risk factor of total mortality in the elderly. Study subjects, design and methods: a total of 1,260 elderly inhabitants (533 men, 727 women) aged 64 years or more from Lieto, South-Western Finland participated the study in 1998-99. Medical records were re-examined approximately a decade later in January 2009. Circulating ox-LDL lipids were used as the main outcome measure. The comparisons were obtained by the Cox hazard ratio model. during the 10-year follow-up, 467 participants had died (37%), of whom 36% had died of atherosclerotic cardiovascular diseases. Ox-LDL was a significant predictor of all-cause mortality, when proportioned to low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c) or apolipoprotein A1 (apoA1). These findings were independent of age, sex, body mass index, smoking, blood pressure and diabetes (P < 0.05 for all). circulating ox-LDL lipids, when proportioned to LDL-c, HDL-c or apoaA1, stand out as a risk factor for all-cause mortality independent of major confounding attributes. In the prospective survival and increasing disease burden caused by accumulating age, oxidative stress may have a considerable role.