Rotavirus vaccination within the South African Expanded Programme on Immunisation

Highlights ► Acute severe dehydrating rotavirus diarrhoea remains an important contributor towards childhood mortality and morbidity and has been well documented in South Africa. ► South Africa is the first country in the WHO African Region to adopt the rotavirus vaccine in the national childhood im...

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Bibliographic Details
Published in:Vaccine 2012-09, Vol.30, p.C14-C20
Main Authors: Seheri, L. Mapaseka, Page, Nicola A, Mawela, Mothahadini P.B, Mphahlele, M. Jeffrey, Steele, A. Duncan
Format: Article
Language:English
Subjects:
Africans
Allergy and Immunology
Blacks
burden of disease
childhood
children
clinical trials
diarrhea
Diarrhea - epidemiology
Diarrhea - mortality
Diarrhea - prevention & control
Diarrhea - virology
Epidemiology
Gastroenteritis - epidemiology
Gastroenteritis - mortality
Gastroenteritis - prevention & control
Gastroenteritis - virology
Humans
Immunization Programs - organization & administration
monitoring
morbidity
mortality
Product Surveillance, Postmarketing
Rotavirus
Rotavirus Infections - epidemiology
Rotavirus Infections - mortality
Rotavirus Infections - prevention & control
Rotavirus Infections - virology
Rotavirus vaccine
Rotavirus Vaccines - administration & dosage
Rotavirus Vaccines - immunology
South Africa
South Africa - epidemiology
vaccination
Vaccination - methods
Vaccine efficacy, Burden of disease
vaccines
Vaccines, Attenuated - administration & dosage
Vaccines, Attenuated - immunology
World Health Organization
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Summary:Highlights ► Acute severe dehydrating rotavirus diarrhoea remains an important contributor towards childhood mortality and morbidity and has been well documented in South Africa. ► South Africa is the first country in the WHO African Region to adopt the rotavirus vaccine in the national childhood immunisation programme in August 2009. ► Studies which facilitated the introduction of rotavirus vaccine in South Africa included the burden of rotavirus disease and strain surveillance, economic burden of rotavirus infection and clinical trials to assess the safety and efficacy of vaccine candidates. ► There is early positive impact of vaccination in reducing the rotavirus burden of disease based on the post-marketing surveillance studies at Dr George Mukhari hospital.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.04.018