Protective Effects of Indomethacin and Cyclophosphamide but Not of Infliximab on Liver Metabolic Changes Caused by Adjuvant-Induced Arthritis

In the study, indomethacin, cyclophosphamide, and infliximab were administered to adjuvant-induced arthritic rats to determine if they were able to prevent the abnormalities caused by arthritis on hepatic metabolism. The drugs were administered to arthritic rats, and at the clinical onset of arthrit...

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Bibliographic Details
Published in:Inflammation 2011-12, Vol.34 (6), p.519-530
Main Authors: da Silva, Maria Angélica Raffaini Covas Pereira, Bersani-Amado, Ciomar Aparecida, Ishii-Iwamoto, Emy Luiza, Bracht, Lívia, Caparroz-Assef, Silvana Martins
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - pharmacology
Antibodies, Monoclonal - therapeutic use
Arthritis, Experimental - drug therapy
Arthritis, Experimental - metabolism
Biomedical and Life Sciences
Biomedicine
Cyclophosphamide - pharmacology
Cyclophosphamide - therapeutic use
Immunology
Indomethacin - pharmacology
Indomethacin - therapeutic use
Inflammation
Infliximab
Internal Medicine
Liver - drug effects
Liver - metabolism
Pathology
Pharmacology/Toxicology
Prostaglandins
Protective Agents
Rats
Rheumatology
Treatment Outcome
Tumor Necrosis Factor-alpha
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Summary:In the study, indomethacin, cyclophosphamide, and infliximab were administered to adjuvant-induced arthritic rats to determine if they were able to prevent the abnormalities caused by arthritis on hepatic metabolism. The drugs were administered to arthritic rats, and at the clinical onset of arthritis (day 14 after adjuvant injection), the livers were perfused to evaluate gluconeogenesis, ureagenesis, oxygen uptake, l -lactate, pyruvate, and ammonia release from l -alanine. The effects of the drugs on body weight gain and the signs of arthritis (paw edema, appearance of secondary lesions, and weights of lymphoid tissues) were also evaluated. Cyclophosphamide could completely prevent liver metabolic changes and the inflammatory response. Indomethacin restored ureagenesis, minimized the decrease in gluconeogenesis, and exerted a partially beneficial effect on inflammatory reactions. Infliximab did not improve arthritis-induced liver metabolic alterations or inflammatory responses. These results suggest the participation of prostaglandins, but not TNF-α, on arthritis-induced liver metabolic alterations.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-010-9259-3