Association of smoking with risk of multiple sclerosis: a population-based study

Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. Several studies have shown an association between smoking and MS risk. Here, in a population-based Canadian cohort, we investigate the relationship between personal and maternal smoking exposure and the...

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Bibliographic Details
Published in:Journal of neurology 2013-07, Vol.260 (7), p.1778-1781
Main Authors: Ramagopalan, Sreeram V., Lee, Joshua D., Yee, Irene M., Guimond, Colleen, Traboulsee, Anthony L., Ebers, George C., Sadovnick, A. Dessa
Format: Article
Language:English
Subjects:
Adult
Canada
Cigarettes
Disease Susceptibility
Female
Households
Humans
Longitudinal Studies
Male
Medicine
Medicine & Public Health
Middle Aged
Multiple sclerosis
Multiple Sclerosis - etiology
Neurology
Neuroradiology
Neurosciences
Odds Ratio
Original Communication
Population-based studies
Pregnancy
Prenatal Exposure Delayed Effects
Questionnaires
Risk Factors
Smoking
Smoking - adverse effects
Surveys and Questionnaires
Tobacco Smoke Pollution - adverse effects
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Summary:Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. Several studies have shown an association between smoking and MS risk. Here, in a population-based Canadian cohort, we investigate the relationship between personal and maternal smoking exposure and the risk of MS. Using the longitudinal Canadian database, 3,157 MS cases and 756 spouse controls were administered questionnaires on active and passive smoking history. Mothers of cases and controls were also asked about their smoking exposure during pregnancy. The MS cases were more likely to have smoked than spouse controls (odds ratio 1.32, 95 % confidence interval 1.10–1.60, p  = 0.003). This association was driven by an excess of ever-smokers in male MS cases. No association was seen with maternal active or passive smoking exposure during pregnancy. Ever-smoking is associated with increased MS risk in males. Further work is needed to understand the mechanism underlying this association.
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-013-6873-7