Retinol-Binding Protein 4 Levels Are Associated with Measures of Liver and Renal Function and Oxidant/Antioxidant Status in Obese Children

Serum retinol-binding protein 4 (RBP4) has been proposed as a metabolic risk factor in obesity. We found that RBP4 levels also were associated with liver enzymes and cystatin C. Oxidant stress is a significant feature in obese children with greater values of RBP4 that can mediate the development of...

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Bibliographic Details
Published in:The Journal of pediatrics 2013-08, Vol.163 (2), p.593-595
Main Authors: Codoñer-Franch, Pilar, MD, PhD, Mora-Herranz, Antonio, MSc, Simó-Jordá, Raquel, MD, Pérez-Rambla, Clara, MSc, Boix-García, Laura, MSc, Faus-Pérez, Alba, MD
Format: Article
Language:English
Subjects:
Adolescent
antioxidants
Antioxidants - metabolism
blood serum
Child
children
comorbidity
enzymes
Female
Humans
Kidney - physiopathology
Kidney Function Tests
liver
Liver - physiopathology
Liver Function Tests
Male
obesity
Obesity - blood
Obesity - metabolism
Obesity - physiopathology
oxidants
Oxidants - metabolism
Oxidative Stress
Pediatrics
renal function
retinol-binding protein
Retinol-Binding Proteins, Plasma - analysis
risk factors
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Summary:Serum retinol-binding protein 4 (RBP4) has been proposed as a metabolic risk factor in obesity. We found that RBP4 levels also were associated with liver enzymes and cystatin C. Oxidant stress is a significant feature in obese children with greater values of RBP4 that can mediate the development of comorbidities.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2013.03.060