Potential Risks of Trimethoprim-Sulfamethoxazole Prophylaxis in Neutropenic Patients

From January 1982 to June 1983 the authors studied the susceptibility to antibiotics of 387 Enterobacteriaceae isolated in our intensive care unit. Thirty percent were resistant to TMP-SMZ. Subgroup analysis with regard to the susceptibility or resistance to TMP-SMZ was performed. The use of TMP-SMZ...

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Bibliographic Details
Published in:The Journal of infectious diseases 1985-05, Vol.151 (5), p.969-969
Main Authors: Riou, B., Richard, C., Rimailho, A., Auzepy, P.
Format: Article
Language:English
Subjects:
Agranulocytosis - complications
Antibiotics
Correspondence
Drug Combinations - adverse effects
Drug Resistance, Microbial
Enterobacteriaceae
Humans
Infections
Neutropenia - complications
Risk
Sulfamethoxazole - adverse effects
Trimethoprim - adverse effects
Trimethoprim, Sulfamethoxazole Drug Combination
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Summary:From January 1982 to June 1983 the authors studied the susceptibility to antibiotics of 387 Enterobacteriaceae isolated in our intensive care unit. Thirty percent were resistant to TMP-SMZ. Subgroup analysis with regard to the susceptibility or resistance to TMP-SMZ was performed. The use of TMP-SMZ prophylaxis in neutropenic patients rests on the following two assumptions: TMP-SMZ might reduce the risk of infection and also the rate of infectious morbidity and mortality without allowing infection due to multiresistant strains. Probable increased resistance of Enterobacteriaceae to TMP-SMZ in the future will greatly reduce the benefits of such prophylaxis.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/151.5.969