Single nucleotide polymorphism in hMLH1 promoter and risk of tobacco-related oral carcinoma in high-risk Asian Indians

hMLH1 is a member of mismatch repair genes (MMR) that plays a crucial role in correcting replication errors, cell cycle arrest, apoptosis and oxidative stress. We explored the risk associated with hMLH1 −93 A>G (rs 1800734) single nucleotide polymorphism (SNP) with the oral squamous cell carcinom...

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Bibliographic Details
Published in:Gene 2013-09, Vol.526 (2), p.223-227
Main Authors: Jha, Ritu, Gaur, Poonam, Sharma, Suresh Chandra, Das, Satya Narayan
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - genetics
Adult
Aged
Aged, 80 and over
Alleles
apoptosis
Asian Indians
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - etiology
Case-Control Studies
cell cycle
Female
Gene Frequency
Genotype
hMLH1
Humans
India - epidemiology
India - ethnology
Male
Middle Aged
Mouth Neoplasms - epidemiology
Mouth Neoplasms - etiology
MutL Protein Homolog 1
Nuclear Proteins - genetics
Oral cancer
oxidative stress
patients
polymerase chain reaction
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
regression analysis
restriction fragment length polymorphism
risk
screening
single nucleotide polymorphism
SNP
squamous cell carcinoma
Tobacco, Smokeless - adverse effects
Young Adult
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Summary:hMLH1 is a member of mismatch repair genes (MMR) that plays a crucial role in correcting replication errors, cell cycle arrest, apoptosis and oxidative stress. We explored the risk associated with hMLH1 −93 A>G (rs 1800734) single nucleotide polymorphism (SNP) with the oral squamous cell carcinoma (OSCC) in Asian Indians. We genotyped 242 patients with tobacco-related OSCC and 205 healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The frequency of AA genotype was found to be significantly (Pc
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2013.05.014