Preeclampsia and ABO blood groups: a systematic review and meta-analysis

Preeclampsia (PE) is a multifactorial pregnancy-specific syndrome which represents one of the leading causes of maternal mortality worldwide. Inherited thrombophilia have been investigated as risk factor for the development of PE and it is currently known that ABO blood group may impact haemostatic...

Full description

Saved in:
Bibliographic Details
Published in:Molecular biology reports 2013-03, Vol.40 (3), p.2253-2261
Main Authors: Alpoim, Patricia Nessralla, de Barros Pinheiro, Melina, Junqueira, Daniela Rezende Garcia, Freitas, Leticia Gonçalves, das Graças Carvalho, Maria, Fernandes, Ana Paula Salles Moura, Komatsuzaki, Flávia, Gomes, Karina Braga, Dusse, Luci Maria Sant’Ana
Format: Article
Language:English
Subjects:
ABO Blood-Group System
Adult
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Blood
Female
Histology
Humans
Life Sciences
Medical disorders
Meta-analysis
Molecular biology
Morphology
Odds Ratio
Pre-Eclampsia - blood
Pregnancy
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Preeclampsia (PE) is a multifactorial pregnancy-specific syndrome which represents one of the leading causes of maternal mortality worldwide. Inherited thrombophilia have been investigated as risk factor for the development of PE and it is currently known that ABO blood group may impact haemostatic balance, having the non-O blood groups (A, B or AB) subjects increased risk for thrombus formation, as compared to those of group O. We performed a systematic review of the literature for published studies investigating whether ABO blood groups could influence PE developing. A sensitive search of four databases identified 45 unique titles. The retrieved papers were assessed independently by authors and a rigorous process of selection and data extract was conduct. Methodological quality of the included studies was also evaluated. Two studies met eligibility criteria. As a main finding of our systematic review, an association between the AB blood group and the occurrence of PE was detected based on two original studies. Considering the role of ABO blood groups on the hemostatic process and thrombus formation, special attention should be given to pregnant patients carrying the AB blood group in order to prevent the syndrome and improve prognosis.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-012-2288-2