Functionalized liposome purification via Liposome Extruder Purification (LEP)

Liposome Extruder Purification (LEP) allows for the rapid purification of diverse liposome formulations using the same extrusion apparatus employed during liposome formation. The LEP process provides a means for purifying functionalized liposomes from non-conjugated drug or protein contaminants with...

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Bibliographic Details
Published in:Analyst (London) 2013-09, Vol.138 (17), p.4746-4751
Main Authors: Alves, Nathan J, Cusick, William, Stefanick, Jared F, Ashley, Jonathan D, Handlogten, Michael W, Bilgicer, Basar
Format: Article
Language:English
Subjects:
Animals
Cattle
Chemical Fractionation - methods
Chemistry, Pharmaceutical
Liposomes - chemistry
Liposomes - isolation & purification
Time Factors
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Summary:Liposome Extruder Purification (LEP) allows for the rapid purification of diverse liposome formulations using the same extrusion apparatus employed during liposome formation. The LEP process provides a means for purifying functionalized liposomes from non-conjugated drug or protein contaminants with >93% liposome recovery and >93% contaminant removal in a single step.
ISSN:0003-2654
1364-5528
DOI:10.1039/c3an00680h