Functionalized liposome purification via Liposome Extruder Purification (LEP)

Liposome Extruder Purification (LEP) allows for the rapid purification of diverse liposome formulations using the same extrusion apparatus employed during liposome formation. The LEP process provides a means for purifying functionalized liposomes from non-conjugated drug or protein contaminants with...

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Published in:Analyst (London) 2013-09, Vol.138 (17), p.4746-4751
Main Authors: Alves, Nathan J, Cusick, William, Stefanick, Jared F, Ashley, Jonathan D, Handlogten, Michael W, Bilgicer, Basar
Format: Article
Language:English
Subjects:
Animals
Cattle
Chemical Fractionation - methods
Chemistry, Pharmaceutical
Liposomes - chemistry
Liposomes - isolation & purification
Time Factors
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description Liposome Extruder Purification (LEP) allows for the rapid purification of diverse liposome formulations using the same extrusion apparatus employed during liposome formation. The LEP process provides a means for purifying functionalized liposomes from non-conjugated drug or protein contaminants with >93% liposome recovery and >93% contaminant removal in a single step.
doi_str_mv 10.1039/c3an00680h
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source Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)
subjects Animals
Cattle
Chemical Fractionation - methods
Chemistry, Pharmaceutical
Liposomes - chemistry
Liposomes - isolation & purification
Time Factors
title Functionalized liposome purification via Liposome Extruder Purification (LEP)
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