Influence of ethanol and methanol gasoline blends on the mutagenicity of particulate exhaust extracts [Salmonella, air pollution]

The Salmonella mutagenicity test was used to evaluate the influence of alcohol fuel extenders on the genetic toxicity of particulate exhaust extracts. Four spark-ignition engine equipped vehicles were operated on gasoline alone. 10% blends of ethanol or methanol in gasoline, and a commercially avail...

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Bibliographic Details
Published in:Archives of environmental contamination and toxicology 1983-05, Vol.12 (3), p.311-317
Main Authors: Clark, C.R, Dutcher, J.S, McClellan, R.O, Naman, T.M, Seizinger, D.E
Format: Article
Language:English
Subjects:
Animals
Ethanol - toxicity
Gasoline - toxicity
In Vitro Techniques
Male
Methanol - toxicity
Mutagens
Petroleum - toxicity
Rats
Rats, Inbred F344
Vehicle Emissions - toxicity
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Summary:The Salmonella mutagenicity test was used to evaluate the influence of alcohol fuel extenders on the genetic toxicity of particulate exhaust extracts. Four spark-ignition engine equipped vehicles were operated on gasoline alone. 10% blends of ethanol or methanol in gasoline, and a commercially available "gasohol". Dichloromethane extracts of the exhaust particles from all tests were mutagenic in Salmonella typhimurium strains TA 100 and TA 98. The extracts were less mutagenic in the nitroductase deficient strains TA 98NR and TA 98DNRP suggesting that nitro substituted polycyclic aromatic hydrocarbons may be responsible for part of the mutagenicity.
ISSN:0090-4341
1432-0703
DOI:10.1007/BF01059408