Activation of the c-myb Locus by Viral Insertional Mutagenesis in Plasmacytoid Lymphosarcomas

Rearrangement in the c-myb locus of each of four independently derived BALB/c plasmacytoid lymphosarcoma (ABPL's) is due to the insertion of a defective Moloney murine leukemia virus (M-MuLV) into a 1.5-kilobase-pair stretch of cellular DNA at the 5′ end of the v-myb-related sequences. This ret...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1984-11, Vol.226 (4678), p.1077-1080
Main Authors: Grace L. C. Shen-Ong, Potter, Michael, Mushinski, J. Frederic, Lavu, Sukadev, Reddy, E. Premkumar
Format: Article
Language:English
Subjects:
Abelson murine leukemia virus
Animals
Base Sequence
Biological and medical sciences
Cancer
Cancer research
Cell physiology
Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
Cellular differentiation
Chromosome Deletion
Cloning, Molecular
DNA
DNA Restriction Enzymes
DNA Transposable Elements
Erythroid progenitor cells
Fundamental and applied biological sciences. Psychology
Genes, Viral
Genetic loci
Genomes
Lymphoma, Non-Hodgkin - genetics
Lymphoma, Non-Hodgkin - microbiology
Mice
Mice, Inbred BALB C
Molecular and cellular biology
Molecular biology
Moloney murine leukemia virus - genetics
Mutation
myb genes
Nucleic Acid Hybridization
Oncogenes
Oncology, Experimental
RNA
Tumors
Viruses
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Summary:Rearrangement in the c-myb locus of each of four independently derived BALB/c plasmacytoid lymphosarcoma (ABPL's) is due to the insertion of a defective Moloney murine leukemia virus (M-MuLV) into a 1.5-kilobase-pair stretch of cellular DNA at the 5′ end of the v-myb-related sequences. This retroviral insertion is associated with abnormal transcription of myb sequences and probably represents a step in the neoplastic transformation of ABPL cells.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6093260