Promoters, toll like receptors and microRNAs: a strange association

Toll-like receptors (TLRs) are proteins that play key role in the innate immune system. In the present study, -1000 base pairs upstream are taken from the transcription start site of the various TLR genes (10 known) in human. About 40 microRNAs have been identified that share 12-19 nucleotide sequen...

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Bibliographic Details
Published in:Indian journal of biochemistry & biophysics 2013-06, Vol.50 (3), p.169-176
Main Authors: Korla, Kalyani, Arrigo, Patrizio, Mitra, Chanchal K
Format: Article
Language:English
Subjects:
Genetic Association Studies - methods
Genome, Human - genetics
Humans
MicroRNAs - genetics
Promoter Regions, Genetic - genetics
Toll-Like Receptors - genetics
Transcriptional Activation - genetics
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Summary:Toll-like receptors (TLRs) are proteins that play key role in the innate immune system. In the present study, -1000 base pairs upstream are taken from the transcription start site of the various TLR genes (10 known) in human. About 40 microRNAs have been identified that share 12-19 nucleotide sequence similarity with the promoter regions of 10 TLRs. It is proposed that the microRNA performs potential role in identification of promoter sequence and initiation of transcription.
ISSN:0301-1208