The Apolipoprotein B/A1 Ratio is Associated with Reactive Oxygen Metabolites and Endothelial Dysfunction in Statin-Treated Patients with Coronary Artery Disease

• Published in: Journal of Atherosclerosis and Thrombosis 2013, Vol.20(7), pp.623-629
• Main Authors: Emoto, Takuo, Sawada, Takahiro, Morimoto, Natsumi, Tenjin, Takako, Wakimoto, Taku, Ikeda, Fumie, Sato, Chiaki, Terashita, Daisuke, Mizoguchi, Taiji, Mizuguchi, Takao, Okamoto, Hiroshi, Matsuo, Yosuke, Kim, Sushi-ku, Takarada, Akira, Yokoyama, Mitsuhiro
• Format: Article
• Language: English
• Subjects: Aged; ApoB/A1 ratio; Apolipoprotein A-I - blood; Apolipoproteins B - blood; Coronary Artery Disease - blood; Coronary Artery Disease - drug therapy; d-ROMs test; Endothelial dysfunction; Endothelium, Vascular - pathology; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Inflammation; Male; Middle Aged; Oxidative Stress; Pilot Projects; Predictive Value of Tests; Prognosis; Reactive Oxygen Species; Risk Factors
• ISSN: 1340-3478; 1880-3873
• DOI: 10.5551/jat.16824

Aim: The prognostic significance of the apolipoprotein B/A1 (ApoB/A1) ratio in statintreated patients with coronary artery disease (CAD) is unknown. We aimed to evaluate the association of the ApoB/A1 ratio with oxidative stress and endothelial dysfunction in these patients. Methods: We enrolled 62 consecutive statin-treated patients who underwent percutaneous coronary intervention (PCI). Their lipid profiles, diacron-reactive oxygen metabolites (d-ROMs), as a marker of oxidative stress, flow-mediated dilatation (FMD), as a marker of vascular endothelial function, and C-reactive protein (CRP) levels, as a marker of inflammation, were measured. Results: Our study population comprised 44 men and 18 women (mean age, 70.5±2.5 years). The ApoB/A1 ratio was positively correlated with the results of the d-ROMs test (p=0.004, r=0.36) and CRP level (p=0.02, r=0.30) and negatively correlated with the %FMD (p=0.005, r=−0.40). A multivariate logistic regression analysis showed that the most powerful predictive factor for the d-ROMs was the ApoB/A1 ratio (p=0.026). We therefore divided patients into two groups according to the cutoff point reported by the INTERHEART study: a low ApoB/A1 ratio (0.641, n=36). The patients with a high ApoB/A1 ratio had higher levels of d-ROMs and CRP, and tended to have a lower %FMD. Conclusion: The ApoB/A1 ratio was associated with the d-ROMs, a marker of oxidative stress, endothelial dysfunction and inflammation, and could be useful as a residual atherosclerotic risk marker to help prevent CAD in statin-treated patients.