The importance of lymph node retrieval and lymph node ratio following preoperative chemoradiation of rectal cancer

Aim Preoperative chemoradiation (CRT) for rectal cancer decreases the number of examined lymph nodes (NELN) found in the resected specimen. However, the prognostic role of lymph node evaluation including overall numbers and the lymph node ratio (LNR) in patients having preoperative CRT have not yet...

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Bibliographic Details
Published in:Colorectal disease 2013-07, Vol.15 (7), p.e382-e388
Main Authors: La Torre, M., Mazzuca, F., Ferri, M., Mari, F. S., Botticelli, A., Pilozzi, E., Lorenzon, L., Osti, M. F., Marchetti, P., Enrici, R. M., Ziparo, V.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma - mortality
Carcinoma - pathology
Carcinoma - therapy
Chemoradiotherapy, Adjuvant - methods
Disease-Free Survival
Female
Humans
Lymph Node Excision - methods
lymph node harvest
lymph node ratio
lymph node retrieval
Lymph Nodes - pathology
Lymph Nodes - surgery
Male
Middle Aged
Multivariate Analysis
neoadjuvant chemoradiotherapy
Prognosis
Proportional Hazards Models
Rectal cancer
Rectal Neoplasms - mortality
Rectal Neoplasms - pathology
Rectal Neoplasms - therapy
Time Factors
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Summary:Aim Preoperative chemoradiation (CRT) for rectal cancer decreases the number of examined lymph nodes (NELN) found in the resected specimen. However, the prognostic role of lymph node evaluation including overall numbers and the lymph node ratio (LNR) in patients having preoperative CRT have not yet been defined. The study has assessed the influence of CRT on the NELN and on lymph node number and LNR on the survival of patients with rectal cancer. Method Between 2003 and 2011, 508 patients with nonmetastatic rectal cancer underwent mesorectal excision. Of these 123 (24.2%) received preoperative CRT. Univariate and multivariate analysis was performed to define the role of NELN and LNR as prognostic indicators of survival. Results Neoadjuvant CRT significantly reduced the NELN (P 
ISSN:1462-8910
1463-1318
DOI:10.1111/codi.12242