Coagulation/Fibrinolysis and laboratory characteristics of pregnant women with severely depressed antithrombin activity

• Published in: Hypertension in pregnancy 2013-08, Vol.32 (3), p.235-244
• Main Authors: Yamada, Takashi, Ishikawa, Satoshi, Kataoka, Soromon, Uda, Tomohiro, Iinuma, Youichiro, Hattori, Rifumi, Yamada, Takahiro, Morikawa, Mamoru, Kaneuchi, Masanori, Minakami, Hisanori
• Format: Article
• Language: English
• Subjects: Acute fatty liver of pregnancy; Antithrombins - blood; Blood Coagulation Disorders - blood; Blood Coagulation Disorders - physiopathology; Creatinine - blood; Disseminated intravascular coagulation; Female; Fibrin Fibrinogen Degradation Products - metabolism; Fibrinogen - metabolism; Fibrinolysis; Humans; Hypertension, Pregnancy-Induced - blood; Liver - physiopathology; Pregnancy; Pregnancy Complications, Hematologic - blood; Pregnancy Complications, Hematologic - physiopathology; Pregnancy-induced antithrombin deficiency; Retrospective Studies; Uric Acid - blood; Vascular permeability
• ISSN: 1064-1955; 1525-6065
• DOI: 10.3109/10641955.2013.792346

Objective: To examine the pathophysiology of reductions in antithrombin (AT) activity during pregnancy and to better characterize the laboratory features of pregnant women with severely depressed AT activity. Methods: Laboratory variables for blood samples obtained within 5 d prior to delivery were compared among three women groups with severely depressed (70%, n = 134). Results: Pregnancy-induced hypertension was present in 16.7% (1/6), 30.0% (3/10), and 9.0% (12/134) of the women with the above-mentioned AT activities, respectively. The AT activities were significantly and negatively correlated with the D-dimer, urate, and creatinine levels. The D-dimer level was significantly and negatively correlated with the fibrinogen level. Women with AT activity