IN VIVO ACTIVITY OF CEFBUPERAZONE (T-1982) AGAINST VARIOUS EXPERIMENTAL INFECTIONS IN MICE

The protective activity of cefbuperazone (T-1982) was compared with those of latamoxef, Cefotaxime, and cefmetazole against intraperitoneal and urinary tract infections in mice. In both tests, cefbuperazone manifested a higher activity than the other cephems against infections with Escherichia coli...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1985, Vol.38(2), pp.249-258
Main Authors: SUZUKI, ISAMU, SENDA, HISATO, YOKOTA, TAKESHI
Format: Article
Language:English
Subjects:
Animals
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Infections - drug therapy
Biological and medical sciences
Blood Bactericidal Activity
Cephamycins - administration & dosage
Cephamycins - blood
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Synergism
Escherichia coli
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
In Vitro Techniques
Klebsiella pneumoniae
Medical sciences
Mice
Microbial Sensitivity Tests
Peritoneal Cavity - microbiology
Pharmacology. Drug treatments
Urinary Tract Infections - drug therapy
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The protective activity of cefbuperazone (T-1982) was compared with those of latamoxef, Cefotaxime, and cefmetazole against intraperitoneal and urinary tract infections in mice. In both tests, cefbuperazone manifested a higher activity than the other cephems against infections with Escherichia coli and Klebsiella pneumoniae. Cefbuperazone also showed a comparatively high degree of prophylactic effect; this activity was observed even when given 4 hours before bacterial challenge. The good in vivo activity of cefbuperazone could not be explained by the differences between the antibiotics on the basis of the serum levels and in vitro activity. Mice, treated with cefbuperazone, showed a statistically significant prolongation of survival time against intraperitoneal challenge with Candida a lbicans, but not when treated with the other cephems. This finding suggests that the host defense mechanisms stimulated by cefbuperazone may contribute to the good in vivo activity of this antibiotic.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.38.249