Sonophoric nanoprobe aided pH measurement in vivousing photoacoustic spectroscopy

Presented here is a novel method of in vivopH sensing utilizing a hybrid optical imaging technique, photoacoustic imaging (PAI), and pH sensitive polymeric nanoprobes. Nanoprobes with hydrophobic core containing a pH sensitive dye were synthesized and used to measure the pH level ex vivofirst and th...

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Bibliographic Details
Published in:Analyst (London) 2013-05, Vol.138 (11), p.3126-3130
Main Authors: Ray, Aniruddha, Yoon, Hyung Ki, Koo Lee, Yong Eun, Kopelman, Raoul, Wang, Xueding
Format: Article
Language:English
Subjects:
Dyes
Leaching
Nanocomposites
Nanomaterials
Nanostructure
Shields
Online Access:Get full text
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Summary:Presented here is a novel method of in vivopH sensing utilizing a hybrid optical imaging technique, photoacoustic imaging (PAI), and pH sensitive polymeric nanoprobes. Nanoprobes with hydrophobic core containing a pH sensitive dye were synthesized and used to measure the pH level ex vivofirst and then in vivoby performing experiments on a rat joint model, with an achieved precision of less than 0.1 pH units. The ability of the hydrophobic functional groups in the polyacrylamide matrix to shield the molecular dye from being affected by the proteins in the plasma, and prevent the dye from leaching out, is also demonstrated.
ISSN:0003-2654
1364-5528
DOI:10.1039/c3an00093a