Determination of triazine residues in herbal plants using molecularly imprinted polymer extraction followed by UPLC-MS/MS

The present study described the development and validation of a sensitive and selective analytical method for simultaneous determination of 23 triazines in herbal plants. Pesticides were extracted using a modified QuEChERS procedure, and the extracts were cleaned up with gel permeation chromatograph...

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Bibliographic Details
Published in:Analytical methods 2013-01, Vol.5 (14), p.3582-3590
Main Authors: Mao, Beiping, Jia, Zhengwei, Mao, Xiuhong, Wang, Ke, Ji, Shen
Format: Article
Language:English
Subjects:
Calibration
Extraction
Imprinted polymers
Mathematical analysis
Monomers
Pesticides
Precipitation
Residues
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Summary:The present study described the development and validation of a sensitive and selective analytical method for simultaneous determination of 23 triazines in herbal plants. Pesticides were extracted using a modified QuEChERS procedure, and the extracts were cleaned up with gel permeation chromatography (GPC) and molecularly imprinted solid-phase extraction (MISPE) followed by UHPLC-MS/MS. The molecularly imprinted polymers (MIPs) were prepared by a traditional precipitation method using N-butylmelamine as a template and methacrylic acid (MAA) as a functional monomer. The linearity of the calibration curve for each pesticide was r super(2) > 0.99 in the concentration range of 0.25 to 50 mu g L super(-1). The validation studies were performed on six herbal plants and the mean recoveries of most triazines were in the range of 60-100% at 0.01, 0.1 and 1.0 mg kg super(-1) with RSD less than 15%. The LODs were less than 0.003 mg kg super(-1). Overall, the method has provided the possibility of applying MIPs to the separation and enrichment of triazines from complicated matrices like herbal plants.
ISSN:1759-9660
1759-9679
DOI:10.1039/c3ay40407b