Capping and in vivo toxicity studies of gold nanoparticles

Water-dispersed colloidal gold nanoparticles (AuNPs) with high concentration were synthesized from metal precursor HAuCl 4 . The bovine serum albumin (BSA) and heterobiofunctionalized thiol polyethylene glycol acid (HS–PEG–COOH) were used as biofunctionalized layers for the synthesized AuNPs. The BS...

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Bibliographic Details
Published in:Advances in natural sciences. Nanoscience and nanotechnology 2012-03, Vol.3 (1), p.15002-1-5
Main Authors: Lien Nghiem, Thi Ha, Nguyen, Thi Tuyen, Fort, Emmanuel, Nguyen, Thanh Phuong, Nhung Hoang, Thi My, Nguyen, Thi Quy, Nhung Tran, Hong
Format: Article
Language:English
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Summary:Water-dispersed colloidal gold nanoparticles (AuNPs) with high concentration were synthesized from metal precursor HAuCl 4 . The bovine serum albumin (BSA) and heterobiofunctionalized thiol polyethylene glycol acid (HS–PEG–COOH) were used as biofunctionalized layers for the synthesized AuNPs. The BSA and HS–PEG–COOH bound to the AuNPs were characterized qualitatively and quantitatively by transmission electron microscope and UV-VS spectrophotometer. The fabricated BSA and HS–PEG–COOH-capped AuNPs were introduced in mouse to study its toxicity and its availability in the liver.
ISSN:2043-6262
2043-6254
2043-6262
DOI:10.1088/2043-6262/3/1/015002