Efficient Isolation and Accurate In Situ Analysis of Circulating Tumor Cells Using Detachable Beads and a High-Pore-Density Filter

Analysis of cancer cells: A new technique isolates rare circulating tumor cells (CTCs) and analyzes their protein expression by the use of detachable beads and high‐pore‐density filters. This technique shows significantly improved efficiency in the isolation of rare CTCs from peripheral blood and en...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-08, Vol.52 (32), p.8337-8340
Main Authors: Lee, Hun Joo, Oh, Jin Ho, Oh, Jin Mi, Park, Jong-Myeon, Lee, Jeong-Gun, Kim, Minseok S., Kim, Yeon Jeong, Kang, Hyun Ju, Jeong, Joon, Kim, Seung Il, Lee, Soo Suk, Choi, Jeong-Woo, Huh, Nam
Format: Article
Language:English
Subjects:
cancer
cell capture
Cell Separation - instrumentation
Cell Separation - methods
circulating tumor cells
Humans
in situ analysis
Neoplastic Cells, Circulating - chemistry
Photolysis
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Summary:Analysis of cancer cells: A new technique isolates rare circulating tumor cells (CTCs) and analyzes their protein expression by the use of detachable beads and high‐pore‐density filters. This technique shows significantly improved efficiency in the isolation of rare CTCs from peripheral blood and enables accurate measurement of in situ protein‐expression levels.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201302278