Effects of lutein supplementation on biological antioxidant status in preterm infants: a randomized clinical trial

Abstract Objective: To test the hypothesis that lutein, compared to the placebo, would enhance the total antioxidant status (TAS) in the preterm infants. Methods: Infants with gestational age (GA) 34 weeks were randomly assigned to receive a daily dose of lutein and zeaxanthin (0.5 mg + 0.02 mg/kg/d...

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Published in:The journal of maternal-fetal & neonatal medicine 2013-09, Vol.26 (13), p.1311-1315
Main Authors: Costa, Simonetta, Giannantonio, Carmen, Romagnoli, Costantino, Vento, Giovanni, Gervasoni, Jacopo, Persichilli, Silvia, Zuppi, Cecilia, Cota, Francesco
Format: Article
Language:English
Subjects:
Administration, Oral
Antioxidant effect
Antioxidants - metabolism
Bottle Feeding
carotenoid supplementation
Dietary Supplements
Double-Blind Method
Female
Health Status
Humans
Infant, Newborn
Infant, Premature - metabolism
Lutein - administration & dosage
Lutein - blood
Lutein - pharmacology
Male
Placebos
premature infants
randomized trial
Xanthophylls - blood
Zeaxanthins
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Summary:Abstract Objective: To test the hypothesis that lutein, compared to the placebo, would enhance the total antioxidant status (TAS) in the preterm infants. Methods: Infants with gestational age (GA) 34 weeks were randomly assigned to receive a daily dose of lutein and zeaxanthin (0.5 mg + 0.02 mg/kg/d) or placebo from the 7th day of life until 40th week of postmenstrual age or until discharge. Results: Seventy-seven preterm infants were randomized (38 in the Lutein group and 39 in the Placebo group) with mean GA of 30.4 (±2.3) weeks and the mean birth weight of 1415 (±457) grams. The TAS did not result statistically different between the two groups during all the study period, but a significant linear correlation was evidenced between plasma lutein concentration and TAS (r = 0.14, p = 0.012) and between plasma zeaxanthin concentration and TAS (r = 0.13, p = 0.02). Conclusions: Supplementation of preterm infants with orally lutein was ineffective in enhancing biological antioxidant capacity. Further studies need to better understand the bioavailability of lutein in the neonatal period in order to identify any best form of supplementation. Trial registration number: UMIN000007041.
ISSN:1476-7058
1476-4954
DOI:10.3109/14767058.2013.783801