Association of Mean Platelet Volume and Pre- and Postinterventional Flow With Infarct-Related Artery in ST-Segment Elevation Myocardial Infarction

Platelets play a role in the pathogenesis of ST-segment elevation myocardial infarction (STEMI). We assessed the relationship between mean platelet volume (MPV) on admission and pre- and postinterventional flow with the infarct-related artery (IRA) in patients with STEMI. We prospectively included 8...

Full description

Saved in:
Bibliographic Details
Published in:Angiology 2013-08, Vol.64 (6), p.440-446
Main Authors: Elbasan, Zafer, Gür, Mustafa, Şahin, Durmuş Yıldıray, Kuloglu, Osman, Icen, Yahya Kemal, Turkoglu, Caner, Ozkan, Bugra, Uysal, Onur Kadir, Kalkan, Gulhan Yuksel, Çaylı, Murat
Format: Article
Language:English
Subjects:
Aged
Blood Platelets
Chi-Square Distribution
Coronary Angiography
Coronary Artery Disease - blood
Coronary Artery Disease - complications
Coronary Artery Disease - diagnosis
Coronary Artery Disease - physiopathology
Coronary Artery Disease - therapy
Coronary Circulation
Echocardiography
Female
Humans
Linear Models
Male
Middle Aged
Multivariate Analysis
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Myocardial Infarction - etiology
Myocardial Infarction - physiopathology
Myocardial Infarction - therapy
Percutaneous Coronary Intervention
Platelet Count
Predictive Value of Tests
Prospective Studies
Regional Blood Flow
Treatment Outcome
Vascular Patency
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Platelets play a role in the pathogenesis of ST-segment elevation myocardial infarction (STEMI). We assessed the relationship between mean platelet volume (MPV) on admission and pre- and postinterventional flow with the infarct-related artery (IRA) in patients with STEMI. We prospectively included 840 patients with STEMI who underwent primary percutaneous coronary intervention (PCI). The patients were divided into 3 groups according to MPV tertiles. Pre- and post-PCI Thrombolysis In Myocardial Infarction (TIMI) flow grade was determined. Initial TIMI flow grade 3 was accepted as patent IRA. After the primary PCI, normal flow was defined as post-PCI TIMI flow 3. When the MPV was increased, the incidence of pre-PCI patent IRA (P = .004) and post-PCI normal TIMI flow (P < .001) was significantly decreased. Multivariate analysis showed that MPV was independently associated with post-PCI TIMI flow grade.
ISSN:0003-3197
1940-1574
DOI:10.1177/0003319712455685