Recyclable and stable silver deposited magnetic nanoparticles with poly (vinyl pyrrolidone)-catechol coated iron oxide for antimicrobial activity

• Published in: Materials Science & Engineering C 2013-10, Vol.33 (7), p.3786-3794
• Main Authors: Mosaiab, Tamim, Jeong, Chan Jin, Shin, Gyo Jic, Choi, Kyung Ho, Lee, Sang Kug, Lee, Iksoo, In, Insik, Park, Sung Young
• Format: Article
• Language: English
• Subjects: Animals; Anti-Infective Agents - pharmacology; Antimicrobial; Catechol; Catechols - chemistry; Catechols - pharmacology; Cell Death - drug effects; Cell Survival - drug effects; Coated Materials, Biocompatible - pharmacology; Dogs; Escherichia coli - drug effects; Ferric Compounds - chemistry; Iron oxide; Madin Darby Canine Kidney Cells; Magnetic Phenomena; Metal Nanoparticles - chemistry; Metal Nanoparticles - ultrastructure; Microbial Sensitivity Tests; Particle Size; Photoelectron Spectroscopy; Pyrrolidinones - chemistry; Recyclable; Recycling; Silver - pharmacology; Silver nanoparticles; Spectrometry, X-Ray Emission; Spectrophotometry, Ultraviolet; Staphylococcus aureus - drug effects
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2013.05.009

This paper introduces a facile method to make highly stable and recyclable antimicrobial magnetic nanoparticles (NPs). Initially, magnetic iron oxide nanoparticles (IONPs) were coated with poly (vinyl pyrrolidone) conjugated catechol (PVP-CCDP). Afterward, silver nanoparticles (Ag0) were deposited onto PVP-CCDP coated IONPs using remain catechol. The prepared nanoparticles showed long term (~4weeks) colloidal stability and redispersibility, respectively, against external magnetic field and over a broad range of pH (4–12). The NPs were characterized by UV–vis, SEM, XPS, and XRD measurements. TEM and DLS analyses showed that the mean particle size of PVP-CCDP coated IONPs/Ag0 were about 72nm. The recyclable magnetic NPs possessed a high antibacterial effect against the model microbes Staphylococcus aureus and Escherichia coli and could be separated easily using magnet following antibacterial test for repeated uses and maintained 100% antibacterial efficiency during three cycles. In MTT assay, the magnetic nanoparticles possessed no measureable cytotoxicity to live cells. Synthesis route of PVP-CCDP coated IONPs/Ag0. [Display omitted] •Catechol conjugated polyvinylpyrrolidone was used to encapsulate magnetic IONPs.•The unbounded catechol moieties strongly reduced AgNO3 and form AgNPs.•This magnetic nanoparticle showed long term colloidal stability against various pH.•The nanoparticles possessed a high antibacterial activity against the model microbes.•Recycled nanoparticles retained 100% antibacterial efficiency in first three cycles.