Hypoxia stimulates 18F-Fluorodeoxyglucose uptake in breast cancer cells via Hypoxia inducible Factor-1 and AMP-activated protein kinase

Hypoxia can stimulate 18F-fluorodeoxyglucose (FDG) uptake in cultured cells. A better understanding of the underlying molecular mechanism is required to determine the value of FDG for studying tumour hypoxia. The effect of hypoxia on FDG uptake, and key proteins involved in glucose transport and gly...

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Bibliographic Details
Published in:Nuclear medicine and biology 2013-08, Vol.40 (6), p.858-864
Main Authors: Smith, Tim A.D., Zanda, Matteo, Fleming, Ian N.
Format: Article
Language:English
Subjects:
AMP-activated protein kinase
AMP-Activated Protein Kinases - metabolism
Biological Transport - drug effects
Breast Neoplasms - pathology
Cell Hypoxia - drug effects
Doxorubicin - pharmacology
Fluorodeoxyglucose
Fluorodeoxyglucose F18 - metabolism
Glucose - metabolism
Humans
Hypoxia
Hypoxia-inducible factor 1
Hypoxia-Inducible Factor 1 - metabolism
MCF-7 Cells
Oncology, Positron Emission Tomography
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Summary:Hypoxia can stimulate 18F-fluorodeoxyglucose (FDG) uptake in cultured cells. A better understanding of the underlying molecular mechanism is required to determine the value of FDG for studying tumour hypoxia. The effect of hypoxia on FDG uptake, and key proteins involved in glucose transport and glycolysis, was studied in MCF7 and MDA231 breast cancer cell lines. Hypoxia induced a dose- and time-dependent increase in FDG uptake. The FDG increase was transient, suggesting that FDG uptake is only likely to be increased by acute hypoxia (
ISSN:0969-8051
1872-9614
DOI:10.1016/j.nucmedbio.2013.05.006