Immunohistochemical Characterization of Neuroendocrine Differentiation of Canine Anal Sac Glandular Tumours

Histological features and expression of neuroendocrine markers were examined in 69 samples of canine anal sac glandular carcinomas (ASGCs). The tumours were classified into solid, rosette and tubular types and mixtures of these types. Tumour-associated death in dogs with solid tumours and mixed tumo...

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Bibliographic Details
Published in:Journal of comparative pathology 2013-08, Vol.149 (2-3), p.199-207
Main Authors: Suzuki, K., Morita, R., Hojo, Y., Nomura, K., Shibutani, M., Mitsumori, K.
Format: Article
Language:English
Subjects:
Anal Gland Neoplasms - metabolism
Anal Gland Neoplasms - pathology
anal glands
anal sac glandular carcinoma
Anal Sacs - metabolism
Anal Sacs - pathology
Animals
Biomarkers, Tumor - analysis
Carcinoma - metabolism
Carcinoma - pathology
Carcinoma - veterinary
Cell Differentiation
death
dog
Dog Diseases - metabolism
Dog Diseases - pathology
Dogs
epithelial cells
Female
Immunohistochemistry
Male
neoplasms
nests
neuroendocrine
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Summary:Histological features and expression of neuroendocrine markers were examined in 69 samples of canine anal sac glandular carcinomas (ASGCs). The tumours were classified into solid, rosette and tubular types and mixtures of these types. Tumour-associated death in dogs with solid tumours and mixed tumours with solid components was higher than in dogs with rosette and tubular type tumours. Chromogranin A immunoreactivity was observed in 28 of 69 samples (40.6%) irrespective of histological type and was localized to the marginal areas of the tumour nest and the basal areas of the tubular and rosette structures. Neuron-specific enolase immunoreactivity in neoplastic epithelial cells was observed in 32 cases (46.4%) and was less frequently observed in the tubular type (14.3%). Synaptophysin expression was present in 15.9% of cases and was least frequent in the tubular type. Twenty-one of the 69 samples expressed more than two neuroendocrine markers and were classified as carcinomas with neuroendocrine differentiation. There was no relationship between neuroendocrine differentiation and clinical outcome. These results suggest that some ASGCs have neuroendocrine differentiation regardless of histological pattern, but clinical outcome is more related to the histological pattern than to neuroendocrine differentiation.
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2013.01.013