Short-term evaluation of autologous transplantation of bone marrow-derived mesenchymal stem cells in patients with cirrhosis: Egyptian study

Background Stem cell–based therapy has received attention as a possible alternative to organ transplantation. The aim of this study was to assess the safety and efficacy of autologous transplantation of bone marrow (BM)–derived stromal cells in post‐HCV liver cirrhosis patients. Methodology 10 × 106...

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Bibliographic Details
Published in:Clinical transplantation 2013-07, Vol.27 (4), p.607-612
Main Authors: Amin, Mona A., Sabry, Dina, Rashed, Laila A., Aref, Wael M., el-Ghobary, Mohamed Ahmed, Farhan, Marwa Salah, Fouad, Hany Ahmed, Youssef, Youssef Abdel-Aziz
Format: Article
Language:English
Subjects:
Adult
Alanine Transaminase - metabolism
Aspartate Aminotransferases - metabolism
Biological and medical sciences
Bone Marrow - surgery
Egypt
Feasibility Studies
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gastroenterology. Liver. Pancreas. Abdomen
human
Humans
intrasplenic injection - liver cirrhosis patients
Liver Cirrhosis - metabolism
Liver Cirrhosis - therapy
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Mesenchymal Stem Cell Transplantation
mesenchymal stem cells
Middle Aged
Other diseases. Semiology
Prognosis
Prospective Studies
Risk Factors
Stromal Cells - transplantation
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue, organ and graft immunology
Transplantation, Autologous
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Summary:Background Stem cell–based therapy has received attention as a possible alternative to organ transplantation. The aim of this study was to assess the safety and efficacy of autologous transplantation of bone marrow (BM)–derived stromal cells in post‐HCV liver cirrhosis patients. Methodology 10 × 106 of isolated human bone marrow (HBM)‐stromal cells in 10 mL normal saline were injected in the spleen of 20 patients with end‐stage liver cirrhosis guided by the ultrasonography, and then patients were followed up on monthly basis for six months. Results A statistically significant decrease was detected in the total bilirubin, aspartate transaminase (AST), alanine transaminase (ALT) (p‐value
ISSN:0902-0063
1399-0012
DOI:10.1111/ctr.12179