Faster Perceptual Learning through Excitotoxic Neurodegeneration

Glutamatergic neural transmission is involved in both neural plasticity [1–3] and neurodegeneration [4–6]. This combination of roles could result in ambivalent effects in which excitotoxic neurodegeneration augments neural plasticity in parallel. Neural plasticity can be induced by exposure-based le...

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Bibliographic Details
Published in:Current biology 2012-10, Vol.22 (20), p.1914-1917
Main Authors: Beste, Christian, Wascher, Edmund, Dinse, Hubert R., Saft, Carsten
Format: Article
Language:English
Subjects:
animal models
Attention
brain
Brain - physiology
cognition
correlation
Electroencephalography
genes
genetic disorders
Humans
Huntington Disease - genetics
learning
Learning - physiology
Long-Term Potentiation
mutation
Neuronal Plasticity - physiology
synaptic transmission
Synaptic Transmission - physiology
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Summary:Glutamatergic neural transmission is involved in both neural plasticity [1–3] and neurodegeneration [4–6]. This combination of roles could result in ambivalent effects in which excitotoxic neurodegeneration augments neural plasticity in parallel. Neural plasticity can be induced by exposure-based learning (EBL) that resembles timing properties of long-term potentiation (LTP) protocols (i.e., LTP-like learning) [7, 8]. Even though it has not been demonstrated so far in animal models that perceptual effects of such stimulation protocols are mediated by typical LTP mechanisms, it has been shown that exposure-based learning exerts strong effects on cognitive brain functioning [9] and is modulated by glutamatergic neural transmission [1]. We reveal that exposure-based perceptual learning is more efficient in a human model of excitotoxic neurodegeneration than in healthy participants. Premanifest Huntington's disease gene mutation carriers showed faster increases in perceptual sensitivities than controls. This in turn changed attentional processing in extrastriate visual areas objectified using electroencephalogram data. The emergence of faster learning correlated positively with genetic disease load. Our results confirm an ambivalent action of increased glutamatergic transmission, implying that the process of excitotoxic neurodegeneration is associated with enhanced perceptual learning, which can be used to improve attentional and behavioral control via the alteration of perceptual sensitivities. ► Neurodegeneration improves long-term potentiation (LTP)-like perceptual learning ► LTP-like learning modulates perceptual sensitivity in visual areas ► These increases foster subsequent attentional selection efficacy
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2012.08.012