Brain tissue volumes in familial longevity: the Leiden Longevity Study

Summary Atrophy is one of the major age‐related changes in the brain. The absence of brain atrophy in elderly individuals reflects deceleration in the process of biological aging. Moreover, results from human twin studies suggest a large genetic influence on the variance of human brain tissue volume...

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Bibliographic Details
Published in:Aging cell 2012-12, Vol.11 (6), p.933-939
Main Authors: Altmann‐Schneider, Irmhild, de Craen, Anton J. M., Slagboom, Pieternella E., Westendorp, Rudi G. J., van Buchem, Mark A., Maier, Andrea B., van der Grond, Jeroen
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Aging - physiology
Amygdala - anatomy & histology
atrophy
Atrophy - pathology
Brain
Case-Control Studies
Confidence intervals
Female
human longevity
Humans
Image Processing, Computer-Assisted
Longevity - physiology
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
neuroimaging
Organ Size
Siblings
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Summary:Summary Atrophy is one of the major age‐related changes in the brain. The absence of brain atrophy in elderly individuals reflects deceleration in the process of biological aging. Moreover, results from human twin studies suggest a large genetic influence on the variance of human brain tissue volumes. To investigate the association of brain volumes with exceptional longevity, we tested whether middle‐aged to elderly offspring of nonagenarian siblings have larger brain volumes than their spouses using magnetic resonance imaging. No differences in whole brain, gray matter and white matter volume were found. These brain volumes were associated with chronological age in offspring and control subjects (all P 
ISSN:1474-9718
1474-9726
DOI:10.1111/j.1474-9726.2012.00868.x