The bile acid receptor, TGR5, regulates basal and cholinergic‐induced secretory responses in rat colon

Bile acids (BA) are becoming increasingly appreciated as enteric hormones that regulate many aspects of intestinal physiology. The BA receptor, TGR5, has been recently shown to be expressed on enteric nerves and enterochromaffin cells (ECs), where its activation regulates small intestinal and coloni...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2013-08, Vol.25 (8), p.708-711
Main Authors: Ward, J. B. J., Mroz, M. S., Keely, S. J.
Format: Article
Language:English
Subjects:
Animals
Bile
bile acid
Bile Acids and Salts - physiology
chloride secretion
Cholic Acids - pharmacology
Cholinergic Neurons - drug effects
Cholinergic Neurons - physiology
Colon
Colon - drug effects
Colon - physiology
Colon - secretion
Epithelial Cells - drug effects
Epithelial Cells - physiology
Epithelial Cells - secretion
epithelial transport
Organ Culture Techniques
Rats
Receptors, G-Protein-Coupled - agonists
Receptors, G-Protein-Coupled - physiology
Rodents
TGR5
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Summary:Bile acids (BA) are becoming increasingly appreciated as enteric hormones that regulate many aspects of intestinal physiology. The BA receptor, TGR5, has been recently shown to be expressed on enteric nerves and enterochromaffin cells (ECs), where its activation regulates small intestinal and colonic motility. Here, we show that TGR5 is also expressed on colonic epithelial cells and that its activation decreases basal secretory tone and inhibits cholinergic‐induced secretory responses. Our data demonstrate a new role for TGR5 in regulating colonic fluid and electrolyte transport and suggest that the receptor represents a good therapeutic target for intestinal transport disorders.
ISSN:1350-1925
1365-2982
DOI:10.1111/nmo.12148