Nanostructured scaffolds for bone tissue engineering

It has been demonstrated that nanostructured materials, compared with conventional materials, may promote greater amounts of specific protein interactions, thereby more efficiently stimulating new bone formation. It has also been indicated that, when features or ingredients of scaffolds are nanoscal...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2013-08, Vol.101A (8), p.2424-2435
Main Authors: Li, Xiaoming, Wang, Lu, Fan, Yubo, Feng, Qingling, Cui, Fu-Zhai, Watari, Fumio
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biotechnology
Bone Development
Bone Regeneration
Bone Substitutes - chemistry
bone tissue engineering
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Humans
Industrial applications and implications. Economical aspects
Medical sciences
Miscellaneous
nanostructure
Nanostructures - chemistry
Nanostructures - ultrastructure
scaffold
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Tissue Engineering - methods
Tissue Scaffolds - chemistry
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Summary:It has been demonstrated that nanostructured materials, compared with conventional materials, may promote greater amounts of specific protein interactions, thereby more efficiently stimulating new bone formation. It has also been indicated that, when features or ingredients of scaffolds are nanoscaled, a variety of interactions can be stimulated at the cellular level. Some of those interactions induce favorable cellular functions while others may leads to toxicity. This review presents the mechanism of interactions between nanoscaled materials and cells and focuses on the current research status of nanostructured scaffolds for bone tissue engineering. Firstly, the main requirements for bone tissue engineering scaffolds were discussed. Then, the mechanism by which nanoscaled materials promote new bone formation was explained, following which the current research status of main types of nanostructured scaffolds for bone tissue engineering was reviewed and discussed. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.34539