Functional nanofiber mat of polyvinyl alcohol/gelatin containing nanoparticles of biphasic calcium phosphate for bone regeneration in rat calvaria defects

New biodegradable mats was successfully obtained by functional polyvinyl alcohol (PVA)/Gelatin (GE) blend fiber mats containing different BCP amounts (20, 40, and 50 w/v%) of biphasic calcium phosphate (BCP) nanoparticles for bone regeneration. BCP nanoparticles were loaded and dispersed successfull...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2013-08, Vol.101A (8), p.2412-2423
Main Authors: Ba Linh, Nguyen Thuy, Lee, Kap-Ho, Lee, Byong-Taek
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biotechnology
biphasic calcium phosphate
Bone Regeneration
Bone Substitutes - chemistry
bone tissue engineering
Cell Line
electrospinning
Fundamental and applied biological sciences. Psychology
gelatin
Gelatin - chemistry
Health. Pharmaceutical industry
Humans
Hydroxyapatites - chemistry
Industrial applications and implications. Economical aspects
Male
Materials Testing
Medical sciences
Miscellaneous
Nanofibers - chemistry
Nanoparticles - chemistry
Orthopedic surgery
Osteoblasts - cytology
polyvinyl alcohol
Polyvinyl Alcohol - chemistry
Rats
Rats, Sprague-Dawley
Skull - injuries
Skull - physiology
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
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Summary:New biodegradable mats was successfully obtained by functional polyvinyl alcohol (PVA)/Gelatin (GE) blend fiber mats containing different BCP amounts (20, 40, and 50 w/v%) of biphasic calcium phosphate (BCP) nanoparticles for bone regeneration. BCP nanoparticles were loaded and dispersed successfully in the PVA/GE fibrous matrix. The addition of BCP was found to have increased fiber diameter, tensile strength, osteoblast cell adhesion, proliferation, and protein expression. Compared to the others, the 50% BCP‐loaded electrospun PVA/GE fibers had the most favorable mechanical properties, cell attachment and growth, and protein expression. In vivo bone formation was examined using rat models, and increased bone formation was observed for the 50% BCP‐loaded electrospun PVA/GE blends within 2 and 4 weeks. This result suggests that the 50% BCP‐PVA/GE composite nanofiber mat has high potential for use in the field of bone regeneration and tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.34533