Catecholamines and their metabolites in the brain and urine of rats with experimental Parkinson's disease

The content of catecholamines and their metabolites in the brain and the relationship between cerebral catecholamine levels and their urinary excretion were studied in rats with 6-OHDA-induced hemiparkinsonism. 6-OHDA reduced brain concentrations of dopamine, DOPAC, and homovanilic acid and urinary...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2000-08, Vol.130 (8), p.805-809
Main Authors: Chekhonin, V P, Baklaushev, V P, Kogan, B M, Savchenko, E A, Lebedev, S V, Man'kovskaya, I V, Filatova, T S, Yusupova, I U, Dmitrieva, T B
Format: Article
Language:English
Subjects:
3,4-Dihydroxyphenylacetic Acid - metabolism
3,4-Dihydroxyphenylacetic Acid - urine
Animals
Brain - metabolism
Brain - pathology
Catecholamines - metabolism
Catecholamines - urine
Dihydroxyphenylalanine - metabolism
Dihydroxyphenylalanine - urine
Dopamine - metabolism
Dopamine - urine
Epinephrine - metabolism
Epinephrine - urine
Homovanillic Acid - metabolism
Homovanillic Acid - urine
Male
Methoxyhydroxyphenylglycol - analogs & derivatives
Methoxyhydroxyphenylglycol - metabolism
Methoxyhydroxyphenylglycol - urine
Norepinephrine - metabolism
Norepinephrine - urine
Oxidopamine - toxicity
Parkinsonian Disorders - chemically induced
Parkinsonian Disorders - metabolism
Parkinsonian Disorders - pathology
Parkinsonian Disorders - urine
Rats
Rats, Wistar
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Summary:The content of catecholamines and their metabolites in the brain and the relationship between cerebral catecholamine levels and their urinary excretion were studied in rats with 6-OHDA-induced hemiparkinsonism. 6-OHDA reduced brain concentrations of dopamine, DOPAC, and homovanilic acid and urinary excretion of dopamine, dioxyphenilalanine, and DOPAC by more than 90%. A positive correlation was found between the concentrations of these metabolites in the urine and striatum. Measurement of urinary catecholamines and their metabolites is a perspective test for evaluating the status of the dopaminergic nigrosostriate system of the brain in experimental parkinsonism.
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02766101