Bactericidal/permeability increasing protein: A multifaceted protein with functions beyond LPS neutralization

Bactericidal permeability increasing protein (BPI), a 55–60 kDa protein, first reported in 1975, has gone a long way as a protein with multifunctional roles. Its classical role in neutralizing endotoxin (LPS) raised high hopes among septic shock patients. Today, BPI is not just a LPS-neutralizing pr...

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Bibliographic Details
Published in:Innate immunity (London, England) England), 2013-08, Vol.19 (4), p.339-347
Main Authors: Balakrishnan, Arjun, Marathe, Sandhya A, Joglekar, Madhura, Chakravortty, Dipshikha
Format: Article
Language:English
Subjects:
Animals
Antimicrobial Cationic Peptides - immunology
Antimicrobial Cationic Peptides - metabolism
Bacteria
Blood Proteins - immunology
Blood Proteins - metabolism
Cell Differentiation
Cell Growth Processes
Chemotaxis
Gram-Negative Bacterial Infections - immunology
Gram-Negative Bacterial Infections - therapy
Humans
Immunity, Innate
Lipopolysaccharides - immunology
Neovascularization, Physiologic
Phagocytosis
Sepsis - immunology
Sepsis - therapy
Signal Transduction - immunology
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Summary:Bactericidal permeability increasing protein (BPI), a 55–60 kDa protein, first reported in 1975, has gone a long way as a protein with multifunctional roles. Its classical role in neutralizing endotoxin (LPS) raised high hopes among septic shock patients. Today, BPI is not just a LPS-neutralizing protein, but a protein with diverse functions. These functions can be as varied as inhibition of endothelial cell growth and inhibition of dendritic cell maturation, or as an anti-angiogenic, chemoattractant or opsonization agent. Though the literature available is extremely limited, it is fascinating to look into how BPI is gaining major importance as a signalling molecule. In this review, we briefly summarize the recent research focused on the multiple roles of BPI and its use as a therapeutic.
ISSN:1753-4259
1753-4267
DOI:10.1177/1753425912465098