Role of superoxide dismutase in the pathogenesis of amyotrophic lateral sclerosis

Activity of cytosolic Cu^sup 2+^/Zn^sup 2+^-superoxide dismutase and total superoxide dismutase activity of the spinal fluid of patients with sporadic amyotrophic lateral sclerosis were measured. These parameters correlates with the form of this disease, its duration, and the severity of neurologica...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1999-04, Vol.127 (4), p.417-419
Main Authors: Zakharova, M. N., Zavalishin, I. A., Boldyrev, A. A., Brusov, O. S., Pavlova, O. A.
Format: Article
Language:English
Subjects:
Amyotrophic lateral sclerosis
Enzymes
Medical research
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Summary:Activity of cytosolic Cu^sup 2+^/Zn^sup 2+^-superoxide dismutase and total superoxide dismutase activity of the spinal fluid of patients with sporadic amyotrophic lateral sclerosis were measured. These parameters correlates with the form of this disease, its duration, and the severity of neurological disorders. Our findings indicate that free-radical processes are involved in the damage to motor neurons in this disease.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02433397