Effects of GABA derivative TZ-50-2 on the autonomic nervous system

GABA derivative TZ-50-2 (4-oxy-3-benzylamino-N-benzylbutanamide hemisuccinate) with pronounced neurotropic (anticonvulsive and local anesthetic) and cardiotonic (antiarrhythmic and antianginal) activities produced a transient facilitation followed by a long-term inhibition of nerve transmission in t...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2000-02, Vol.129 (2), p.164-167
Main Authors: Galenko-Yaroshevskii, P. A., Uvarov, A. V., Linchenko, S. N., Popkov, B. L., Sheikh-Zade, Yu. P., Cherednik, I. L.
Format: Article
Language:English
Subjects:
Nervous system
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Summary:GABA derivative TZ-50-2 (4-oxy-3-benzylamino-N-benzylbutanamide hemisuccinate) with pronounced neurotropic (anticonvulsive and local anesthetic) and cardiotonic (antiarrhythmic and antianginal) activities produced a transient facilitation followed by a long-term inhibition of nerve transmission in the parasympathetic and, especially, sympathetic ganglia in acute experiments on cats. TZ-50-2 reduced sensitivity of adrenal chromaffin cells and cholinoreceptors of the carotid glomeruli to cytisine.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02434800