Effects of Dexamethasone on the Development of Neonatal Rats and Level of Active Caspase-3 in Brain Cortex

Dexamethasone increased the levels of active caspase-3 form in the brain cortex of neonatal rats 120 h after drug administration, but did not affect the expression of this key apoptotic protease in the brain 6 or 24 h postinjection. Increased expression of the active form of caspase-3 in the cerebra...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2012-08, Vol.153 (4), p.478-480
Main Authors: Menshanov, P. N., Muzyka, V. V., Dygalo, N. N.
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Animals, Newborn - growth & development
Apoptosis
Biomedical and Life Sciences
Biomedicine
Brain
Caspase 3 - metabolism
Cell Biology
Cerebral Cortex - metabolism
Densitometry
Dexamethasone
Dexamethasone - pharmacology
Glucocorticoids - pharmacology
Growth and Development - drug effects
Internal Medicine
Laboratory Medicine
Pathology
Proteases
Rats
Rats, Wistar
Reflex, Startle - drug effects
Time Factors
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Summary:Dexamethasone increased the levels of active caspase-3 form in the brain cortex of neonatal rats 120 h after drug administration, but did not affect the expression of this key apoptotic protease in the brain 6 or 24 h postinjection. Increased expression of the active form of caspase-3 in the cerebral cortex was associated with earlier eye opening and delayed formation of startle-reflex in rats.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1745-1