Myocardial sympathetic innervation, function, and oxidative metabolism in non-infarcted myocardium in patients with prior myocardial infarction

Objective The purpose of this study was to investigate the relationship between sympathetic innervation, contractile function, and the oxidative metabolism of the non-infarcted myocardium in patients with prior myocardial infarction. Methods In 19 patients (14 men, 5 women, 65 ± 9 years) after prior...

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Bibliographic Details
Published in:Annals of nuclear medicine 2013-07, Vol.27 (6), p.523-531
Main Authors: Aoki, Hirofumi, Matsunari, Ichiro, Nomura, Yusuke, Fujita, Wataru, Komatsu, Ryoko, Miyazaki, Yoshiharu, Nekolla, Stephan G., Kajinami, Kouji
Format: Article
Language:English
Subjects:
Aged
Electrocardiography
Female
Heart - innervation
Humans
Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Myocardial Infarction - diagnostic imaging
Myocardial Infarction - metabolism
Myocardial Infarction - physiopathology
Myocardium - metabolism
Nuclear Medicine
Original Article
Oxidation-Reduction
Positron-Emission Tomography
Radiology
Sympathetic Nervous System - physiopathology
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Summary:Objective The purpose of this study was to investigate the relationship between sympathetic innervation, contractile function, and the oxidative metabolism of the non-infarcted myocardium in patients with prior myocardial infarction. Methods In 19 patients (14 men, 5 women, 65 ± 9 years) after prior myocardial infarction, sympathetic innervation was assessed by 11 C-hydroxyephedrine (HED) positron emission tomography (PET). Oxidative metabolism was quantified using 11 C-acetate PET. Left ventricular systolic function was measured by echocardiography with speckle tracking technique. Results The 11 C-HED retention was positively correlated with left ventricular ejection fraction (LVEF) ( r  = 0.566, P  
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-013-0716-6