Psychotropic activity of cholecystokinine tetrapeptide analogs

Psychotropic activity of two cholecystokinin analogs Trp-R^sub 1^-Asp-Phe-NH^sub 2^ and R^sub 2^-Trp-R^sub 3^-Asp-Phe-NH^sub 2^ is studied using behavioral tests. Both analogs have no effect on motor activity. Trp-R^sub 1^-Asp-Phe-NH^sub 2^ in doses of 0.1 and 0.3 mg/kg exhibits anxiogenic activity...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1998-06, Vol.125 (6), p.573-575
Main Authors: Anokhina, I. P., Bespalova, Zh. D., Proskuryakova, T. V., Pankratova, N. V., Pal'keeva, M. E., Petrichenko, O. B.
Format: Article
Language:English
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Summary:Psychotropic activity of two cholecystokinin analogs Trp-R^sub 1^-Asp-Phe-NH^sub 2^ and R^sub 2^-Trp-R^sub 3^-Asp-Phe-NH^sub 2^ is studied using behavioral tests. Both analogs have no effect on motor activity. Trp-R^sub 1^-Asp-Phe-NH^sub 2^ in doses of 0.1 and 0.3 mg/kg exhibits anxiogenic activity and impairs learning (only in a dose of 0.1 mg/kg) of experimental animals. R^sub 2^-Trp-R^sub 3^-Asp-Phe-NH^sub 2^ possesses no anxiogenic activity and in doses of 0.1 and 0.3 mg/kg promotes learning, which attests to its nootropic activity.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02445243