Different antiarrhythmic effects of dalargin and β-endorphin in severe myocardial ischemia during stimulation of the sensorimotor cortex

The effects of the opiate receptor agonists dalargin and beta -endorphin on the occurrence of idioventricular arrhythmias, including ventricular tachycardia and fibrillation, are studied in acute experiments on Nembutal-anesthetized cats. Dalargin administered in the dose crossing the blood-brain ba...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1997-07, Vol.124 (1), p.645-647
Main Authors: Mikhailova, S. D., Storozhakov, G. I., Kudinova, A. V., Semushkina, T. M.
Format: Article
Language:English
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Summary:The effects of the opiate receptor agonists dalargin and beta -endorphin on the occurrence of idioventricular arrhythmias, including ventricular tachycardia and fibrillation, are studied in acute experiments on Nembutal-anesthetized cats. Dalargin administered in the dose crossing the blood-brain barrier produces a pronounced antiarrhythmic effect, while beta -endorphin is effective only against ventricular fibrillation.
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02445050