Sensory Neuron-Derived Eph Regulates Glomerular Arbors and Modulatory Function of a Central Serotonergic Neuron: e1003452

Olfactory sensory neurons connect to the antennal lobe of the fly to create the primary units for processing odor cues, the glomeruli. Unique amongst antennal-lobe neurons is an identified wide-field serotonergic neuron, the contralaterally-projecting, serotonin-immunoreactive deutocerebral neuron (...

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Bibliographic Details
Published in:PLoS genetics 2013-04, Vol.9 (4)
Main Authors: Singh, Ajeet Pratap, Das, Rudra Nayan, Rao, Gururaj, Aggarwal, Aman, Diegelmann, Soeren, Evers, Jan Felix, Karandikar, Hrishikesh, Landgraf, Matthias, Rodrigues, Veronica, VijayRaghavan, K
Format: Article
Language:English
Subjects:
Animals
Behavior
Brain research
Insects
Neurons
Odors
Rodents
Serotonin
Online Access:Get full text
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Summary:Olfactory sensory neurons connect to the antennal lobe of the fly to create the primary units for processing odor cues, the glomeruli. Unique amongst antennal-lobe neurons is an identified wide-field serotonergic neuron, the contralaterally-projecting, serotonin-immunoreactive deutocerebral neuron (CSDn). The CSDn spreads its termini all over the contralateral antennal lobe, suggesting a diffuse neuromodulatory role. A closer examination, however, reveals a restricted pattern of the CSDn arborization in some glomeruli. We show that sensory neuron-derived Eph interacts with Ephrin in the CSDn, to regulate these arborizations. Behavioural analysis of animals with altered Eph-ephrin signaling and with consequent arborization defects suggests that neuromodulation requires local glomerular-specific patterning of the CSDn termini. Our results show the importance of developmental regulation of terminal arborization of even the diffuse modulatory neurons to allow them to route sensory-inputs according to the behavioural contexts.
ISSN:1553-7390
1553-7404
DOI:10.1371/journal.pgen.1003452