Study the effects of zonisamide on fine structure of rabbit basilar artery and hippocampus in rabbit subarachnoid hemorrhage model

Background In this study, we investigated the effect of a novel antiepileptic drug, zonisamide (ZNS), on the basilar artery and hippocampus in a rabbit subarachnoid hemorrhage (SAH) model. Methods Three groups of New Zealand white rabbits were used: a sham (non-SAH) group, an SAH + saline group, and...

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Bibliographic Details
Published in:Acta neurochirurgica 2013-08, Vol.155 (8), p.1531-1537
Main Authors: Demirci, Adnan Yalcin, Seckin, Hakan, Besalti, Omer, Arikok, Ata Turker, Yigitkanli, Tolga, Caliskan, Murat, Yigitkanli, Kazim, Bavbek, Murad
Format: Article
Language:English
Subjects:
Animals
Basilar Artery - drug effects
Basilar Artery - pathology
Disease Models, Animal
Experimental Research - Vascular
Hippocampus - blood supply
Hippocampus - drug effects
Interventional Radiology
Isoxazoles - therapeutic use
Male
Medicine
Medicine & Public Health
Minimally Invasive Surgery
Neurology
Neuroradiology
Neurosurgery
Rabbits
Subarachnoid Hemorrhage - drug therapy
Surgical Orthopedics
Vasospasm, Intracranial - drug therapy
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Summary:Background In this study, we investigated the effect of a novel antiepileptic drug, zonisamide (ZNS), on the basilar artery and hippocampus in a rabbit subarachnoid hemorrhage (SAH) model. Methods Three groups of New Zealand white rabbits were used: a sham (non-SAH) group, an SAH + saline group, and SAH + drug treatment group that received ZNS. In the treatment group, the subjects were given ZNS for 3 days after the SAH. Hippocampal sections were evaluated for neural tissue degeneration. Basilar artery lumen areas and arterial wall thickness were also measured in all groups. Results The mean luminal area of the SAH + ZNS was significantly greater than the SAH + saline group. In addition, the arterial wall thickness of SAH + ZNS group was significantly thinner than the SAH + saline group. The neuronal degeneration scores of the hippocampal CA1 regions in the SAH + ZNS group were significantly lower than the SAH + saline treatment animals. Conclusions These results indicate that ZNS has a vasodilatatory effect on the basilar artery and a neuronal protective effect in the CA1 region of the hippocampus in a rabbit SAH model.
ISSN:0001-6268
0942-0940
DOI:10.1007/s00701-013-1726-9