When too much ATP is a bad thing: a pivotal role for P2X7 receptors in motor neuron degeneration

As ATP is released in the CNS following both relatively minor inflammatory events, as well as major responses to trauma and ischemia, a complex balancing act is required to maintain the inflammatory machinery, including P2X7 receptors, in neuroprotection mode. As a result, P2X7 receptors have garner...

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Bibliographic Details
Published in:Journal of neurochemistry 2013-08, Vol.126 (3), p.301-304
Main Author: Browne, Susan E.
Format: Article
Language:English
Subjects:
Adenosine triphosphatase
Animals
Apoptosis - physiology
fas Receptor - metabolism
Inflammatory diseases
Motor Neurons - metabolism
Nervous system
Neurochemistry
Neurons
Peroxynitrous Acid - metabolism
Receptors, Purinergic P2X7 - metabolism
Signal Transduction - physiology
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Summary:As ATP is released in the CNS following both relatively minor inflammatory events, as well as major responses to trauma and ischemia, a complex balancing act is required to maintain the inflammatory machinery, including P2X7 receptors, in neuroprotection mode. As a result, P2X7 receptors have garnered a great deal of interest as potential therapeutic targets for disorders involving neuroinflammation. Gandelman et al examine whether ATP might also directly target motor neurons, as P2X7 receptors are located on motor neuron axons in addition to surrounding astroglial cells.
ISSN:0022-3042
1471-4159
DOI:10.1111/jnc.12321