The Chemopreventive Capacity of Quercetin to Induce Programmed Cell Death in Hepatocarcinogenesis

In this study of chemoprevention in the rat modified resistant hepatocyte model, preneoplastic cells were diminished by >60% with quercetin pretreatment compared with those rats treated with N-Diethylnitrosamine (DEN) to induce liver cancer. This decrease occurred associated with an abolished DEN...

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Bibliographic Details
Published in:Toxicologic pathology 2013-08, Vol.41 (6), p.857-865
Main Authors: Vásquez-Garzón, Verónica Rocío, Macias-Pérez, José Roberto, Jiménez-García, Mónica Noemí, Villegas, Vanessa, Fattel-Fazenta, Samia, Villa-Treviño, Saúl
Format: Article
Language:English
Subjects:
Animals
Anticarcinogenic Agents - pharmacology
Antineoplastic Agents - pharmacology
Apoptosis - drug effects
Biological and medical sciences
Carcinogenesis - drug effects
Carcinogenesis, carcinogens and anticarcinogens
Caspases - metabolism
Chemical agents
Chemoprevention - methods
Gastroenterology. Liver. Pancreas. Abdomen
Liver - chemistry
Liver - drug effects
Liver - pathology
Liver Neoplasms, Experimental - chemistry
Liver Neoplasms, Experimental - metabolism
Liver Neoplasms, Experimental - pathology
Liver Neoplasms, Experimental - prevention & control
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Oxidative Stress - drug effects
Precancerous Conditions - chemistry
Precancerous Conditions - drug therapy
Precancerous Conditions - metabolism
Precancerous Conditions - pathology
Quercetin - pharmacology
Rats
Rats, Inbred F344
Toxicology
Tumors
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Summary:In this study of chemoprevention in the rat modified resistant hepatocyte model, preneoplastic cells were diminished by >60% with quercetin pretreatment compared with those rats treated with N-Diethylnitrosamine (DEN) to induce liver cancer. This decrease occurred associated with an abolished DEN-induced lipid peroxidation as well as activation of caspase 9 and increased caspase 3, as determined by increased expression of cleaved caspase 3 and 9, but not cleaved caspase 8 and increased fragmentation of Poly (ADP-ribose) polymerase (PARP) inducing apoptosis of presumed genetically injured cells, when quercetin was administered before the initiation agent.
ISSN:0192-6233
1533-1601
DOI:10.1177/0192623312467522