Gonadotropin-inhibitory hormone (GnIH), GnIH receptor and cell signaling

Highlights • G protein-coupled receptor 147 (GPR147) is the receptor for GnIH. • GPR147 is coupled to Gαi protein. • GnIH inhibits GnRH-induced adenylate cyclase/cAMP/PKA dependent ERK pathway.

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Bibliographic Details
Published in:General and comparative endocrinology 2013-09, Vol.190, p.10-17
Main Authors: Ubuka, Takayoshi, Son, You Lee, Bentley, George E, Millar, Robert P, Tsutsui, Kazuyoshi
Format: Article
Language:English
Subjects:
Animals
COS Cells
Endocrinology & Metabolism
Glycoproteins - metabolism
Gonadotropin-inhibitory hormone
Gonadotropin-releasing hormone
Gonadotropin-Releasing Hormone - metabolism
Gonadotropins
GPR147
Humans
LβT2 cells
Peptide Hormones - metabolism
Receptors, Neuropeptide - metabolism
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Description
Summary:Highlights • G protein-coupled receptor 147 (GPR147) is the receptor for GnIH. • GPR147 is coupled to Gαi protein. • GnIH inhibits GnRH-induced adenylate cyclase/cAMP/PKA dependent ERK pathway.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2013.02.030